Dysphagia in Parkinson´s disease. A 5-year follow-up study

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2025年2月19日

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Diego Santos-García,
Teresa de Deus Fonticoba,
Silvia Jesús,
Marina Cosgaya,
Juan García Caldentey,
Nuria Caballol,
Ines Legarda,
Jorge Hernández Vara,
Iria Cabo,
Lydia López Manzanares,
Isabel González Aramburu,
Maria A. Ávila Rivera,
Víctor Gómez Mayordomo,
Víctor Nogueira,
Julio Dotor García-Soto,
Carmen Borrué,
Berta Solano Vila,
María Álvarez Sauco,
Lydia Vela,
Sonia Escalante,
Esther Cubo,
Zebenzui Mendoza,
Isabel Pareés,
Pilar Sánchez Alonso,
Maria G. Alonso Losada,
Nuria López Ariztegui,
Itziar Gastón,
Jaime Kulisevsky,
Manuel Seijo,
Caridad Valero,
Ruben Alonso Redondo,
Carlos Ordás,
Manuel Menéndez-González,
Darrian McAfee,
Pablo Martinez-Martin,
Pablo Mir,
A. D. Adarmes,
M. Almeria,
M. G. Alonso Losada,
A. Alonso Cánovas,
F. Alonso Frech,
R. Alonso Redondo,
I. Álvarez,
M. Álvarez Sauco,
A. Aneiros Díaz,
S. Arnáiz,
S. Arribas,
A. Ascunce Vidondo,
M. Aguilar,
M. A. Ávila,
N. Bernardo Lambrich,
H. Bejr-Kasem,
M. Blázquez Estrada,
M. Botí,
C. Borrue,
M. T. Buongiorno,
C. Cabello González,
I. Cabo López,
N. Caballol,
A. Cámara Lorenzo,
H. Canfield Medina,
E. Carabajal Pendón,
F. Carrillo,
F. J. Carrillo Padilla,
E. Casas,
M. J. Catalán,
P. Clavero,
A. Cortina Fernández,
M. Cosgaya,
A. Cots Foraster,
A. Crespo Cuevas,
E. Cubo,
T. de Deus Fonticoba,
O. de Fábregues-Boixar,
M. Díez-Fairen,
J. Dotor García-Soto,
E. Erro,
S. Escalante,
E. Estelrich Peyret,
N. Fernández Guillán,
P. Gámez,
M. Gallego,
J. García Caldentey,
C. García Campos,
C. García Díez,
J. M. García Moreno,
I. Gastón,
M. P. Gómez Garre,
V. Gómez Mayordomo,
J. González Aloy,
I. González-Aramburu,
J. González Ardura,
B. González García,
M. J. González Palmás,
G. R. González Toledo,
A. Golpe Díaz,
M. Grau Solá,
G. Guardia,
J. Hernández Vara,
A. Horta-Barba,
D. Idoate Calderón,
J. Infante,
S. Jesús,
J. Kulisevsky,
M. Kurtis,
C. Labandeira,
M. A. Labrador,
F. Lacruz,
M. Lage Castro,
S. Lastres Gómez,
I. Legarda,
N. López Ariztegui,
L. M. López Díaz,
D. López Domínguez,
L. López Manzanares,
B. López Seoane,
S. del Lucas Pozo,
Y. Macías,
M. Mata,
G. Martí Andres,
M. J. Martí,
J. C. Martínez Castrillo,
P. Martinez-Martin,
D. McAfee,
M. T. Meitín,
Z. Mendoza Plasencia,
M. Menéndez González,
C. Méndez del Barrio,
P. Mir,
J. Miranda Santiago,
M. I. Morales Casado,
A. Moreno Diéguez,
I. Muro García,
V. Nogueira,
A. Novo Amado,
S. Novo Ponte,
C. Ordás,
J. Pagonabarraga,
I. Pareés,
B. Pascual-Sedano,
P. Pastor,
A. Pérez Fuertes,
R. Pérez Noguera,
A. Planas-Ballvé,
L. Planellas,
M. A. Prats,
C. Prieto Jurczynska,
V. Puente,
M. Pueyo Morlans,
A. Puig Daví,
N. Redondo Rafales,
L. Rodríguez Méndez,
A. B. Rodríguez Pérez,
F. Roldán,
M. Ruíz De Arcos,
J. Ruíz Martínez,
P. Sánchez Alonso,
M. Sánchez-Carpintero,
G. Sánchez Díez,
A. Sánchez Rodríguez,
P. Santacruz,
D. Santos García,
J. C. Segundo Rodríguez,
M. Seijo,
M. Sierra Peña,
B. Solano Vila,
E. Suárez Castro,
J. P. Tartari,
C. Valero,
L. Vargas,
L. Vela,
C. Villanueva,
B. Vives

摘要

Background and objective

Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinson´s disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors.

Patients and methods

Patients with early PD (≤ 2 years from symptoms onset) who were recruited from January/2016 to November/2017 (baseline visit; V0) and evaluated annually for 5 years from the Spanish cohort COPPADIS were included in this prospective study. Controls were assessed at baseline and at 2-, 4-, and 5-year follow-up. Dysphagia was defined as a score ≥ 1 in the item 20 of the Non-Motor Symptoms Scale (NMSS).

Results

Dysphagia was more frequent at baseline in PD patients (19.6% [36/184]; 62.3 ± 8.3 years old; 56.8% males) than in controls (5.3% [11/206]; 60.9 ± 8.3 years old; 50% males) (p < 0.0001) and in all visits as well (p < 0.0001). A worse quality of sleep (Parkinson´s Disease Sleep Scale; OR = 0.974; p = 0.005), a greater impulse-control behavior (ICB) (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale; OR = 1.066; p = 0.014), and non-motor symptoms burden (Non-Motor Symptoms Scale; OR = 1.016; p = 0.021) were independent factors associated with dysphagia at baseline. In those subjects with dysphagia, no differences were observed between patients and controls in the mean NMSS-item 20 overtime, and it didn´t change throughout the follow-up.

Conclusion

Dysphagia was frequent in early PD patients compared to controls. However, it was minor and did not progress over time. Sleep, ICB, and non-motor symptoms burden were related to dysphagia.