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<p>Incretin mimetics, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), have demonstrated unprecedented efficacy in obesity management. However, their primary mechanisms, such as appetite suppression and delayed gastric emptying, significantly reduce the total energy intake, which can lead to nutritional risks, including essential micronutrient deficiencies and reduced lean body mass, which negatively affects physical function and metabolic rate. This review examined nutritional management strategies to address these issues. This review proposes comprehensive management strategies that focus on preserving muscle health and nutritional status. This review introduces the concept of ‘Companion Food Systems’, an integrated nutritional strategy that coordinates nutrient-dense foods, strategic nutrient pairing, adjunctive nutritional support, and pharmacokinetic-tailored chrononutrition to maintain protein and micronutrient delivery within a reduced-intake setting. This integrated approach aims to support lean mass preservation and overall metabolic health during incretin mimetic-induced weight loss.</p>

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Orchestrating muscle health and nutritional integrity via companion food systems during incretin-mimetics induced weight loss

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • Taemin Kim,
  • Jeongyeon Seo,
  • Sumin Kang,
  • Hyun Kyung Kim,
  • Bogyeong Lee,
  • Junhee Lee,
  • Gwang-woong Go

摘要

Incretin mimetics, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), have demonstrated unprecedented efficacy in obesity management. However, their primary mechanisms, such as appetite suppression and delayed gastric emptying, significantly reduce the total energy intake, which can lead to nutritional risks, including essential micronutrient deficiencies and reduced lean body mass, which negatively affects physical function and metabolic rate. This review examined nutritional management strategies to address these issues. This review proposes comprehensive management strategies that focus on preserving muscle health and nutritional status. This review introduces the concept of ‘Companion Food Systems’, an integrated nutritional strategy that coordinates nutrient-dense foods, strategic nutrient pairing, adjunctive nutritional support, and pharmacokinetic-tailored chrononutrition to maintain protein and micronutrient delivery within a reduced-intake setting. This integrated approach aims to support lean mass preservation and overall metabolic health during incretin mimetic-induced weight loss.