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<p>This study investigated the effects of health-functional products on short-chain fatty acids (SCFAs) production using an <i>ex</i> <i>vivo</i> gut simulation platform alongside a human pilot study. The research proceeded in three phases: screening of 11 commercially available products (e.g., omega-3, vitamins/minerals, plant protein, and dietary fiber products) with fecal samples from 15 healthy individuals, validation of four candidates with 30 participants, and a two-month pilot trial with 32 subjects consuming the most effective product. Among the tested products, a plant-based protein consistently increased SCFAs production, particularly butyrate, in the <i>ex</i> <i>vivo</i> system. The pilot study corroborated these findings, with 85% of participants showing elevated fecal SCFAs and 62.5% exhibiting increased butyrate. Participants also reported improved stool consistency and reduced abdominal discomfort. Overall, these results indicate that health-functional products can promote beneficial microbial fermentation, supporting their use as evidence-based functional ingredients and in personalized dietary strategies for gut health optimization.</p>

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Effects of health-functional products on gut microbiota-derived short-chain fatty acids production: an ex vivo and pilot human study

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Dong Ho Suh,
  • Hyo-Jin Lee,
  • Yosep Ji,
  • Wilhelm H. Holzapfel,
  • Matthew K. Runyon,
  • Hae Jo,
  • Jung-Yoon Hur,
  • Seung Min Jeong,
  • Eun Sung Jung

摘要

This study investigated the effects of health-functional products on short-chain fatty acids (SCFAs) production using an ex vivo gut simulation platform alongside a human pilot study. The research proceeded in three phases: screening of 11 commercially available products (e.g., omega-3, vitamins/minerals, plant protein, and dietary fiber products) with fecal samples from 15 healthy individuals, validation of four candidates with 30 participants, and a two-month pilot trial with 32 subjects consuming the most effective product. Among the tested products, a plant-based protein consistently increased SCFAs production, particularly butyrate, in the ex vivo system. The pilot study corroborated these findings, with 85% of participants showing elevated fecal SCFAs and 62.5% exhibiting increased butyrate. Participants also reported improved stool consistency and reduced abdominal discomfort. Overall, these results indicate that health-functional products can promote beneficial microbial fermentation, supporting their use as evidence-based functional ingredients and in personalized dietary strategies for gut health optimization.