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<p>Cereals are staple foods and a primary source of energy in both developed and developing countries. Rich in carbohydrates, they also contain micronutrients, including Ca, Zn, and Fe. However, the bioaccessibility of these micronutrients is limited due to factors including the cellular structure of cereals, the chemical form in which nutrients are stored, and the presence of antinutritional compounds like phytates. This limitation in bioaccessibility poses public health challenges. This review examines strategies to improve micronutrient bioaccessibility in cereals, including chelating agents, enzyme treatment and fermentation (increase Fe and Zn bioaccessibility two-threefold), delivery systems and microencapsulation, drug nutrient interactions, and traditional methods. The review also covers biofortification and nutrient pairing strategies that enhance absorption. Notably, it highlights the practical relevance of these biotechnological strategies and assesses their practical implementation. Overall, enzyme-assisted processing combined with targeted fortification emerges as the most feasible near-term strategy for improving mineral nutrition from cereal-based foods.</p> Graphical abstract <p></p>

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A review of role and applications of adjuvants in enhancing bioaccessibility of mineral in cereals

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Swara Kalantre,
  • Sahil Bipinkumar Suthar,
  • Nikhita Boda Ramesh,
  • Parth Sarin,
  • Sakshi Rai,
  • Santosh Kumar Banjara,
  • Rajendran Ananthan,
  • Paras Sharma,
  • Sourav Sengupta,
  • Shivalingsarj Desai,
  • Devaraj Parasannanavar

摘要

Cereals are staple foods and a primary source of energy in both developed and developing countries. Rich in carbohydrates, they also contain micronutrients, including Ca, Zn, and Fe. However, the bioaccessibility of these micronutrients is limited due to factors including the cellular structure of cereals, the chemical form in which nutrients are stored, and the presence of antinutritional compounds like phytates. This limitation in bioaccessibility poses public health challenges. This review examines strategies to improve micronutrient bioaccessibility in cereals, including chelating agents, enzyme treatment and fermentation (increase Fe and Zn bioaccessibility two-threefold), delivery systems and microencapsulation, drug nutrient interactions, and traditional methods. The review also covers biofortification and nutrient pairing strategies that enhance absorption. Notably, it highlights the practical relevance of these biotechnological strategies and assesses their practical implementation. Overall, enzyme-assisted processing combined with targeted fortification emerges as the most feasible near-term strategy for improving mineral nutrition from cereal-based foods.

Graphical abstract