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<p>Burdock (<i>Arctium lappa</i> L.), a pharmaco-culinary plant, is characterized by its high dietary fiber content. In this study, the bioaccessibility, polyphenol composition, and anti-inflammatory activity of bound polyphenols from burdock root dietary fiber (BRDF-BP) were investigated. In vitro digestion and colon fermentation results showed that BRDF-BP was mainly released from BRDF during the colon fermentation stage. BRDF-BP was characterized by HPLC-ESI-QTOF-MS/MS, revealing 23 polyphenols including four phenolic acids, one stilbene, and 18 flavonoids. BRDF-BP significantly ameliorated the LPS-induced inflammatory response in RAW264.7 cells by reducing ROS generation, inhibiting the secretion of inflammatory factors, and increasing antioxidant enzyme activities. Transcriptome results showed that BRDF-BP treatment significantly downregulated five inflammatory response-related signaling pathways, including NOD-like receptors, IL-17, and JAK-STAT. Network topology analysis revealed that <i>Stat1</i> is a hub gene for BRDF-BP, which exerts anti-inflammatory effects. In conclusion, this study illustrates that BRDF-BP can be liberated during colonic fermentation and exhibits anti-inflammatory properties.</p>

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Bioaccessibility, composition, and anti-inflammtory activity of bound polyphenols from burdock (Arctium lappa L.) root insoluble dietary fiber

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Jue Cui,
  • Yu He,
  • Nannan Zhao,
  • Yani Wu,
  • Shuai Wang,
  • Haixu Xu

摘要

Burdock (Arctium lappa L.), a pharmaco-culinary plant, is characterized by its high dietary fiber content. In this study, the bioaccessibility, polyphenol composition, and anti-inflammatory activity of bound polyphenols from burdock root dietary fiber (BRDF-BP) were investigated. In vitro digestion and colon fermentation results showed that BRDF-BP was mainly released from BRDF during the colon fermentation stage. BRDF-BP was characterized by HPLC-ESI-QTOF-MS/MS, revealing 23 polyphenols including four phenolic acids, one stilbene, and 18 flavonoids. BRDF-BP significantly ameliorated the LPS-induced inflammatory response in RAW264.7 cells by reducing ROS generation, inhibiting the secretion of inflammatory factors, and increasing antioxidant enzyme activities. Transcriptome results showed that BRDF-BP treatment significantly downregulated five inflammatory response-related signaling pathways, including NOD-like receptors, IL-17, and JAK-STAT. Network topology analysis revealed that Stat1 is a hub gene for BRDF-BP, which exerts anti-inflammatory effects. In conclusion, this study illustrates that BRDF-BP can be liberated during colonic fermentation and exhibits anti-inflammatory properties.