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<p>Hangovers are a set of unpleasant symptoms following excessive alcohol intake. This study evaluated the effects of <i>Lactobacillus-</i>fermented garlic extract (LFGE) on hangover symptoms in a randomized, double-blind, placebo-controlled, crossover trial involving 25 participants. Hangover severity was assessed using the Acute Hangover Scale (AHS) at 1, 2, 4, and 15&#xa0;h post-consumption, while blood alcohol and acetaldehyde levels were measured at multiple time points up to 15&#xa0;h. LFGE significantly reduced total AHS scores at all-time points compared to placebo (<i>p</i> &lt; 0.05), with notable improvements in thirst (15&#xa0;h, <i>p</i> = 0.0023), headache (4&#xa0;h, <i>p</i> = 0.026), and fatigue (4&#xa0;h, <i>p</i> = 0.0162). Blood alcohol concentrations were also significantly lower in the LFGE group at 0.25, 0.5, and 1&#xa0;h (<i>p</i> &lt; 0.05). These results suggest that LFGE may enhance alcohol metabolism and has potential as a functional food ingredient for hangover relief.</p>

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Effects of Lactobacillus-fermented garlic extract on hangover relief: a randomized, double-blind, placebo-controlled crossover study

  • 期刊论文

  • 发表日期：

    2026年1月2日

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  • HyunCheol Jeong,
  • Yu-Bin Moon,
  • YeRin Kim,
  • Johann Sohn,
  • Doohyeon Lim,
  • Juhee Lee,
  • Seunghun Lee

摘要

Hangovers are a set of unpleasant symptoms following excessive alcohol intake. This study evaluated the effects of Lactobacillus-fermented garlic extract (LFGE) on hangover symptoms in a randomized, double-blind, placebo-controlled, crossover trial involving 25 participants. Hangover severity was assessed using the Acute Hangover Scale (AHS) at 1, 2, 4, and 15 h post-consumption, while blood alcohol and acetaldehyde levels were measured at multiple time points up to 15 h. LFGE significantly reduced total AHS scores at all-time points compared to placebo (p < 0.05), with notable improvements in thirst (15 h, p = 0.0023), headache (4 h, p = 0.026), and fatigue (4 h, p = 0.0162). Blood alcohol concentrations were also significantly lower in the LFGE group at 0.25, 0.5, and 1 h (p < 0.05). These results suggest that LFGE may enhance alcohol metabolism and has potential as a functional food ingredient for hangover relief.