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<p>Tofu, a traditional food made from soybeans, has been widely consumed in the world but tofu production generates significant by-products such as tofu whey, and other residues. In the present study, Aquaforte, derived from tofu whey, was investigated for its antioxidative and anti-inflammatory properties in combating oxidative stress-induced damage in human keratinocytes (HaCaT). Antioxidant capacities were assessed through antioxidant properties were evaluated through DPPH and ABTS assays in which the Aquaforte samples demonstrated superior efficacy. In AAPH induced oxidative stress model, Aquaforte significantly suppressed intracellular reactive oxygen species levels, enhanced cell viability, and accelerated cellular migration in the wound healing assay, suggesting its potential in tissue regeneration. Furthermore, Aquaforte reduced the formation of senescence-associated heterochromatin foci. Additionally, quantitative real-time PCR analysis showed that Aquaforte decreased interlukin-6 expression and upregulated nuclear factor erythroid 2-related factor 2. This research contributes to sustainable upcycling by valorizing tofu whey by-products into beneficial bioactive compounds.</p>

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Inflammation-suppressing effects of tofu whey-derived Aquaforte on human keratinocytes stimulated with 2,2’-azobis(2-amidinopropane) dihydrochloride

  • 期刊论文

  • 发表日期：

    2025年9月6日

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  • Seong Hwan Bae,
  • Hyo Ri Shin,
  • Do Young An,
  • Ji Eun Lee,
  • Kangwook Lee,
  • La Yoon Choi,
  • Nam Su Oh,
  • Tae Jin Cho,
  • Tae Yoon Kim,
  • Martin J. T. Reaney,
  • Youn Young Shim,
  • Ju Hee Kim,
  • Hee-Seok Lee,
  • Jae Kyeom Kim

摘要

Tofu, a traditional food made from soybeans, has been widely consumed in the world but tofu production generates significant by-products such as tofu whey, and other residues. In the present study, Aquaforte, derived from tofu whey, was investigated for its antioxidative and anti-inflammatory properties in combating oxidative stress-induced damage in human keratinocytes (HaCaT). Antioxidant capacities were assessed through antioxidant properties were evaluated through DPPH and ABTS assays in which the Aquaforte samples demonstrated superior efficacy. In AAPH induced oxidative stress model, Aquaforte significantly suppressed intracellular reactive oxygen species levels, enhanced cell viability, and accelerated cellular migration in the wound healing assay, suggesting its potential in tissue regeneration. Furthermore, Aquaforte reduced the formation of senescence-associated heterochromatin foci. Additionally, quantitative real-time PCR analysis showed that Aquaforte decreased interlukin-6 expression and upregulated nuclear factor erythroid 2-related factor 2. This research contributes to sustainable upcycling by valorizing tofu whey by-products into beneficial bioactive compounds.