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<p><i>Hibiscus sabdariffa</i> calyx is widely used in traditional medicine and as a food ingredient due to its antioxidant potential. This study investigated the toxicological and antioxidant effects of calyx extracts obtained after drying at four temperatures (−&#xa0;58&#xa0;°C, 30&#xa0;°C, 40&#xa0;°C, and 50&#xa0;°C) in Wistar rats. Acute toxicity was assessed following the modified Lorke method (24-h observation), and chronic toxicity was evaluated over 28&#xa0;days using doses of 250, 500, and 1000&#xa0;mg/kg, in accordance with OECD guideline 407. Although no signs of acute toxicity or significant alterations in organ weights were observed, the antioxidant markers—GSH, CAT, and SOD—were dose-dependently enhanced, with the most potent activity recorded in extracts dried at 30&#xa0;°C. These findings suggest that drying at 30&#xa0;°C preserves key bioactive compounds, thereby maximizing the antioxidant potential of <i>H. sabdariffa calyx</i>. The study provides practical insights for optimizing processing conditions for medicinal and nutraceutical applications.</p>

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Toxicological and antioxidant evaluations of the effects of different drying temperatures of the calyx of Hibiscus sabdariffa in experimental rats

  • 期刊论文

  • 发表日期：

    2025年4月30日

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  • John Osarenren Efosa,
  • Kingsley Omage,
  • Marshall Arebojie Azeke

摘要

Hibiscus sabdariffa calyx is widely used in traditional medicine and as a food ingredient due to its antioxidant potential. This study investigated the toxicological and antioxidant effects of calyx extracts obtained after drying at four temperatures (− 58 °C, 30 °C, 40 °C, and 50 °C) in Wistar rats. Acute toxicity was assessed following the modified Lorke method (24-h observation), and chronic toxicity was evaluated over 28 days using doses of 250, 500, and 1000 mg/kg, in accordance with OECD guideline 407. Although no signs of acute toxicity or significant alterations in organ weights were observed, the antioxidant markers—GSH, CAT, and SOD—were dose-dependently enhanced, with the most potent activity recorded in extracts dried at 30 °C. These findings suggest that drying at 30 °C preserves key bioactive compounds, thereby maximizing the antioxidant potential of H. sabdariffa calyx. The study provides practical insights for optimizing processing conditions for medicinal and nutraceutical applications.