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<p>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction. Despite the availability of various treatment options, many patients remain refractory to conventional therapies. Recent advancements in cellular immunotherapy, particularly chimeric antigen receptor T-cell (CAR-T cell) therapy, have demonstrated promising potential in targeting the underlying immunological mechanisms of RA. This paper explores the rationale for CAR-T cell therapy in RA, the mechanisms by which CAR-T cells may exert therapeutic effects, the current state of clinical research, and the challenges that need to be addressed for the successful implementation of CAR-T cell immunotherapy in RA treatment. We also discuss future directions for improving the safety and efficacy of CAR-T cell therapy in autoimmune diseases.</p>

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Potential of CAR-T cell immunotherapy in rheumatoid arthritis

  • 期刊论文

  • 发表日期：

    2026年4月8日

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  • Ian C. Chikanza,
  • Lazaros I. Sakkas

摘要

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction. Despite the availability of various treatment options, many patients remain refractory to conventional therapies. Recent advancements in cellular immunotherapy, particularly chimeric antigen receptor T-cell (CAR-T cell) therapy, have demonstrated promising potential in targeting the underlying immunological mechanisms of RA. This paper explores the rationale for CAR-T cell therapy in RA, the mechanisms by which CAR-T cells may exert therapeutic effects, the current state of clinical research, and the challenges that need to be addressed for the successful implementation of CAR-T cell immunotherapy in RA treatment. We also discuss future directions for improving the safety and efficacy of CAR-T cell therapy in autoimmune diseases.