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<p>Autoimmune diseases result from the immune system’s inability to distinguish between self and non-self, destroying healthy tissue. T regulatory cells (Tregs) are a unique subset of CD4 + T cells, which play a crucial role in immune tolerance and preventing autoimmunity. Their capacity to quell an exaggerated immune reaction establishes them as a potential point for therapeutic intervention. However, utilizing Tregs’ intrinsic repressive nature on other immune cells to prevent or halt autoimmunity and inflammation poses challenges in compromising pathogen clearance and in the place of restraining anti-tumor immune responses. This review outlines the biology of Tregs, their position concerning autoimmune rheumatic disease, obstacles to exploiting their therapeutic potential, and the evolution of Treg-based treatment.</p>

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Regulatory T cells as a potential treatment for autoimmune inflammatory rheumatic and musculoskeletal diseases

  • 期刊论文

  • 发表日期：

    2026年4月5日

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  • Ian C. Chikanza,
  • Clementine Sifiso Nomalizo Mnkandla-Khumalo,
  • Lazaros I. Sakkas

摘要

Autoimmune diseases result from the immune system’s inability to distinguish between self and non-self, destroying healthy tissue. T regulatory cells (Tregs) are a unique subset of CD4 + T cells, which play a crucial role in immune tolerance and preventing autoimmunity. Their capacity to quell an exaggerated immune reaction establishes them as a potential point for therapeutic intervention. However, utilizing Tregs’ intrinsic repressive nature on other immune cells to prevent or halt autoimmunity and inflammation poses challenges in compromising pathogen clearance and in the place of restraining anti-tumor immune responses. This review outlines the biology of Tregs, their position concerning autoimmune rheumatic disease, obstacles to exploiting their therapeutic potential, and the evolution of Treg-based treatment.