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Objective <p>Inflammatory bowel diseases (IBDs) can be associated with bone fragility. We aimed to evaluate bone mineral density (BMD) in patients with IBD.</p> Methods <p>In this observational cross-sectional study, we consecutively included patients with IBD without previous diagnosis of low BMD. All patients underwent a standardized evaluation that included laboratory testing, dual-energy X-ray absorptiometry at the lumbar spine and hip to measure BMD and a systematic evaluation by a rheumatologist.</p> Results <p>We included 339 patients with IBD; 64% were women, and the median (interquartile range) age was 42 (32–53) years. BMD assessment revealed osteopenia in 115 (34%) patients and osteoporosis in 40 (12%). Multivariable analysis did not identify variables associated with low BMD. After the evaluation by the rheumatologist, vitamin D supplementation was initiated for 153 (45%) patients, and anti-osteoporosis treatment was started for 24 (7%).</p> Conclusion <p>In this large cohort study, about 46% of patients with IBD had low BMD. Systematic evaluation led to the initiation of treatments in most patients. Altogether, our results promote multidisciplinary care of patients with IBD.<Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> <p><b>Key points</b></p> <p>• <i>Low bone mass density occurs in 42% of patients with inflammatory bowel diseases.</i></p> <p>• <i>Age and female sex are associated with low bone mass density. After the evaluation by&#xa0;the rheumatologist, vitamin D supplementation and anti-osteoporosis treatment were initiated&#xa0;in a large number of patients.</i></p> <p>• <i>A systematic multidisciplinary assessment for bone fragility could lead to better care of&#xa0;patients with inflammatory bowel disease.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

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Screening for osteoporosis in patients with inflammatory bowel diseases: a cross-sectional study

  • 期刊论文

  • 发表日期：

    2026年3月23日

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  • Sébastien Ottaviani,
  • Xavier Tréton,
  • Marine Forien,
  • Carmen Stefanescu,
  • Pierre-Antoine Juge,
  • Solène Dermine,
  • Anne-Laure Pelletier,
  • Hakim Becheur,
  • Esther Ebstein,
  • Yoram Bouhnik,
  • Philippe Dieudé

摘要

Objective

Inflammatory bowel diseases (IBDs) can be associated with bone fragility. We aimed to evaluate bone mineral density (BMD) in patients with IBD.

Methods

In this observational cross-sectional study, we consecutively included patients with IBD without previous diagnosis of low BMD. All patients underwent a standardized evaluation that included laboratory testing, dual-energy X-ray absorptiometry at the lumbar spine and hip to measure BMD and a systematic evaluation by a rheumatologist.

Results

We included 339 patients with IBD; 64% were women, and the median (interquartile range) age was 42 (32–53) years. BMD assessment revealed osteopenia in 115 (34%) patients and osteoporosis in 40 (12%). Multivariable analysis did not identify variables associated with low BMD. After the evaluation by the rheumatologist, vitamin D supplementation was initiated for 153 (45%) patients, and anti-osteoporosis treatment was started for 24 (7%).

Conclusion

In this large cohort study, about 46% of patients with IBD had low BMD. Systematic evaluation led to the initiation of treatments in most patients. Altogether, our results promote multidisciplinary care of patients with IBD.

Key points

• Low bone mass density occurs in 42% of patients with inflammatory bowel diseases.

• Age and female sex are associated with low bone mass density. After the evaluation by the rheumatologist, vitamin D supplementation and anti-osteoporosis treatment were initiated in a large number of patients.

• A systematic multidisciplinary assessment for bone fragility could lead to better care of patients with inflammatory bowel disease.