Scholarlink

Objective <p>Osteoarthritis (OA) has been a major public health challenge. The role of non-negligible dietary factors in the development of OA and in mortality risk among OA patients is unclear. This study aims to investigate the associations of serum carotenoid levels with mortality in OA patients.</p> Methods <p>We analyzed data from 2051 OA patients in NHANES III. Mortality through December 31, 2019, was determined via the National Death Index. We assessed associations between carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene) and mortality using cubic splines and Cox regression. Sensitivity and stratified analyses were performed.</p> Results <p>Overall, 942 deaths occurred during a median 12.58-year follow-up. Higher quartiles of all carotenoids (except lutein/zeaxanthin) were associated with lower all-cause mortality (hazard ratios and 95% confidence intervals: 0.53 [0.41, 0.67], 0.74 [0.59, 0.95], 0.75 [0.59, 0.96], and 0.66 [0.51, 0.86] for α-carotene, β-carotene, β-cryptoxanthin, and lycopene). BMI modified the relationship between β-carotene and mortality, showing a protective effect with BMI &lt; 30&#xa0;kg/m<sup>2</sup>.</p> Conclusion <p>Higher serum carotenoid levels are linked to reduced mortality. While suggesting potential benefits, carotenoid supplement use remains questionable due to possible antioxidant interactions and synergistic effects.</p> <p><Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> <p><b>Key Points</b></p> <p>• <i>Higher quartiles of all carotenoids (except lutein/zeaxanthin) were related to lower all-cause mortality.</i></p> <p>• <i>Elevated serum carotenoid levels were associated with a decreased risk of mortality.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between serum carotenoid concentrations and risk of all-cause and cause-specific mortality in individuals with osteoarthritis

  • 期刊论文

  • 发表日期：

    2026年1月26日

查看全文
  • Shaofang Cai,
  • Jing Wang,
  • Yaoyao Nie,
  • Jiayao Fan,
  • Rui Gao,
  • Sara Moazzen,
  • Minmin Jiang

摘要

Objective

Osteoarthritis (OA) has been a major public health challenge. The role of non-negligible dietary factors in the development of OA and in mortality risk among OA patients is unclear. This study aims to investigate the associations of serum carotenoid levels with mortality in OA patients.

Methods

We analyzed data from 2051 OA patients in NHANES III. Mortality through December 31, 2019, was determined via the National Death Index. We assessed associations between carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene) and mortality using cubic splines and Cox regression. Sensitivity and stratified analyses were performed.

Results

Overall, 942 deaths occurred during a median 12.58-year follow-up. Higher quartiles of all carotenoids (except lutein/zeaxanthin) were associated with lower all-cause mortality (hazard ratios and 95% confidence intervals: 0.53 [0.41, 0.67], 0.74 [0.59, 0.95], 0.75 [0.59, 0.96], and 0.66 [0.51, 0.86] for α-carotene, β-carotene, β-cryptoxanthin, and lycopene). BMI modified the relationship between β-carotene and mortality, showing a protective effect with BMI < 30 kg/m2.

Conclusion

Higher serum carotenoid levels are linked to reduced mortality. While suggesting potential benefits, carotenoid supplement use remains questionable due to possible antioxidant interactions and synergistic effects.

Key Points

• Higher quartiles of all carotenoids (except lutein/zeaxanthin) were related to lower all-cause mortality.

• Elevated serum carotenoid levels were associated with a decreased risk of mortality.