Objective <p>Myocardial work (MW) is a novel indicator measured by noninvasive echocardiography, which could detect subclinical myocardial dysfunction before reduction of left ventricular ejection fraction (LVEF). The study aimed to evaluate subclinical myocardial dysfunction in patients with systemic sclerosis (SSc) with normal LVEF, using left ventricular MW through two-dimensional speckle-tracking imaging (2D-STI).</p> Method <p>Eighty patients with SSc, which included 40 diffuse skin type SSc (dcSSc) and 40 limited skin type SSc (lcSSc) according to LeRoy’s criteria, and 40 gender and age matched health subjects were enrolled. The images were collected using standard transthoracic echocardiography. Global longitudinal strain (GLS), global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were obtained.</p> Results <p>Our study showed that there were no significant differences in LVEF and GLS between the SSc group and the control group. Both the lcSSc group and the dcSSc group had lower GWI, GCW, and GWE and higher GWW than the control group (<i>P</i> &lt; 0.05). GWI, GCW, and GWE were lower in the dcSSc group than those in the lcSSc group, while GWW was higher in the dcSSc group (<i>P</i> &lt; 0.05). GWI and GCW were positively correlated with LVEF (<i>P</i> &lt; 0.001). GWI, GCW, and GWE were negatively correlated with GLS (<i>P</i> &lt; 0.001), and GWW was positively correlated with GLS (<i>P</i> &lt; 0.05). Elevated CRP was associated with reduced GWI and GCW (<i>P</i> &lt; 0.05).</p> Conclusions <p>Our study demonstrates the presence of subclinical myocardial dysfunction in SSc patients. The dcSSc patients may be more prone to have subclinical myocardial dysfunction than the lcSSc patients. Noninvasive left ventricular myocardial work may be a promising novel tool for detection of subclinical myocardial dysfunction.</p>