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<p>Parkinson’s disease (PD) is a complex disorder with contributions by environmental and genetic factors. <i>LRRK2</i> R1628P is a major genetic risk factor for developing PD in Asian populations. However, the effect of this variant in Kinh Vietnamese remains unclear. This study collected DNA samples of 832 subjects comprising 190 PD patients and 642 control cases, and the <i>LRRK2</i> R1628P variant was genotyped using an allele-specific oligonucleotide PCR method. The prevalence of the GC genotype of <i>LRRK2</i> R1628P was significantly higher in the PD group than in the control group, and the <i>LRRK2</i> R1628P variant showed a significant association with PD with OR = 2.91 (95% CI = 1.50–5.62). <i>LRRK2</i> R1628P was also found to be associated with PD in subpopulations for males, early-onset, and late-onset. These results emphasize the important genetic contribution of <i>LRRK2</i> R1628P in the risk of developing PD in the Kinh Vietnamese population.</p>

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Association of LRRK2 R1628P variant with Parkinson’s disease in Kinh Vietnamese: a cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年7月31日

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  • Minh Duc Do,
  • Tai Ngoc Tran,
  • Linh Hoang Gia Le,
  • Thao Phuong Mai

摘要

Parkinson’s disease (PD) is a complex disorder with contributions by environmental and genetic factors. LRRK2 R1628P is a major genetic risk factor for developing PD in Asian populations. However, the effect of this variant in Kinh Vietnamese remains unclear. This study collected DNA samples of 832 subjects comprising 190 PD patients and 642 control cases, and the LRRK2 R1628P variant was genotyped using an allele-specific oligonucleotide PCR method. The prevalence of the GC genotype of LRRK2 R1628P was significantly higher in the PD group than in the control group, and the LRRK2 R1628P variant showed a significant association with PD with OR = 2.91 (95% CI = 1.50–5.62). LRRK2 R1628P was also found to be associated with PD in subpopulations for males, early-onset, and late-onset. These results emphasize the important genetic contribution of LRRK2 R1628P in the risk of developing PD in the Kinh Vietnamese population.