Purpose <p>Mesh suture is a suture device designed to distribute pressure at the suture-tissue interface to decrease suture pull-through. The primary aim of this study was to evaluate the feasibility and short-term clinical outcomes in isolated umbilical hernia repairs.</p> Methods <p>A retrospective cohort of patients undergoing umbilical hernia repair using mesh suture was analyzed between January 2023–2025. Patients were identified through institutional implant logs. Outcomes evaluated included surgical site infection (SSI), surgical site events (SSE), hernia recurrence, readmissions, and reoperations.</p> Results <p>Fifty-eight isolated umbilical hernia repairs with mesh suture were performed by twenty-four surgeons. The mean hernia width was 1.7&#xa0;cm (± 0.7). The 90-day SSI rate was 5.2% (<i>n</i> = 3), consisting of two superficial infections and one organ space infection. The 90-day SSE rate was 5.2% (<i>n</i> = 1 fascial dehiscence, <i>n</i> = 2 hematomas). There were seven readmissions (12.1%) within 90 days, of which only one was related to the abdominal wall closure. There were three reoperations within 90 days (5.2%): two hematoma washouts and one fascial dehiscence repair. The mean length of follow up was 594 days (± 284). There were no cases of hernia recurrence.</p> Conclusions <p>Mesh suture provides the simplicity of suture repair with increased force distribution properties of mesh. In this initial multicenter experience, mesh suture demonstrated feasibility and acceptable short-term clinical outcomes for isolated umbilical hernia repair. Future randomized controlled trials comparing mesh suture versus planar mesh and standard suture are needed to compare techniques most effectively.</p>