Scholarlink

Background <p>Polyester (PET)-based meshes are widely employed in hernia repair due to their superior mechanical properties and biocompatibility. However, their multifilament nature promotes bacterial adhesion and biofilm formation, increasing the risk of postoperative infections and recurrence.</p> Method <p>In this research, polyethylene terephthalate (PET) mesh was functionalized with chitosan using layer-by-layer coating in chitosan and citric acid layers. The PET meshes were soaked in chitosan and citric acid for 5 times and 10 times layer by layer to see the weight variance of both coated meshes. Moreover, chitosan coated PET meshes were loaded with levofloxacin for antibacterial properties.</p> Results <p>The functionalized PET meshes were thoroughly characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. SEM images confirmed the uniform deposition of the chitosan coating on the PET meshes. While EDX revealed the presence of deposited chitosan and levofloxacin HCL. The FTIR confirmed the successful cross-linking of chitosan with PET mesh. The antimicrobial efficacy of the coated meshes was assessed against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> using the agar diffusion method. The results demonstrated excellent antimicrobial activity, with minimum inhibition zones up to 10&#xa0;mm. The antibacterial levofloxacin demonstrated the release performance of a soluble drug and inhibited bacterial growth. The PET coated with chitosan 10 times showed better results of the antibacterial inhibition zone in comparison to the 5-times layer-by-layer coated PET meshes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Enhancing the antimicrobial efficacy of polyester hernia meshes via layer-by-layer chitosan surface modification

  • 期刊论文

  • 发表日期：

    2026年7月23日

查看全文
  • Dost Ali,
  • Sheeza Rukhsar,
  • Noor Sanbhal,
  • Sadaf Tagar,
  • Mazhar Ali Peerzada,
  • Mazhar Ali Sanbhal,
  • Hamza Ali Khan

摘要

Background

Polyester (PET)-based meshes are widely employed in hernia repair due to their superior mechanical properties and biocompatibility. However, their multifilament nature promotes bacterial adhesion and biofilm formation, increasing the risk of postoperative infections and recurrence.

Method

In this research, polyethylene terephthalate (PET) mesh was functionalized with chitosan using layer-by-layer coating in chitosan and citric acid layers. The PET meshes were soaked in chitosan and citric acid for 5 times and 10 times layer by layer to see the weight variance of both coated meshes. Moreover, chitosan coated PET meshes were loaded with levofloxacin for antibacterial properties.

Results

The functionalized PET meshes were thoroughly characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. SEM images confirmed the uniform deposition of the chitosan coating on the PET meshes. While EDX revealed the presence of deposited chitosan and levofloxacin HCL. The FTIR confirmed the successful cross-linking of chitosan with PET mesh. The antimicrobial efficacy of the coated meshes was assessed against Staphylococcus aureus and Escherichia coli using the agar diffusion method. The results demonstrated excellent antimicrobial activity, with minimum inhibition zones up to 10 mm. The antibacterial levofloxacin demonstrated the release performance of a soluble drug and inhibited bacterial growth. The PET coated with chitosan 10 times showed better results of the antibacterial inhibition zone in comparison to the 5-times layer-by-layer coated PET meshes.