In this paper, we consider the Cauchy problem for a semilinear damped wave equation with the nonlinear term \(|u|^{1+\frac{2}{n}}\mu (|u|)\) , where \(\mu \) is a modulus of continuity. In recent papers by Ebert–Girardi–Reissig (Math. Ann. 378, 1311–1326, 2020) and Girardi (Nonlinear Differ. Equ. Appl. 32, 3, 2025), the authors obtained a sharp critical condition on \(\mu \) in low space dimensions \(n=1,2,3\) , which determines the threshold between global (in time) existence of small data solutions and blow-up of solutions in finite time. Our new results are to prove that this condition remains valid in dimension \(n=4\) , together with the asymptotic profiles of global solutions. From this, we see that the behavior of the solution at \(t \rightarrow \infty \) is identified by the Gauss kernel. Finally, a sharp lower lifespan estimate for blow-up solutions is also derived in the case when blow-up occurs.