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<p>The inflation of breast cancer has been edging to increased cancer-associated morbidity and fatality over the years. The casualty of the detection of biomarkers often deters the proper treatment of the disease. This work discusses the facile alloy/dealloying process for electrochemical detection of the breast cancer biomarker, phenylalanine (Phe). The co-deposition of silver-gold (Ag-Au) alloy at a constant potential on the electrochemically deposited sulfur-doped carbon nanotubes (S-CNT//GCE), forming AgAu/S-CNT//GCE, is consecutively dealloyed to form a highly selective sensor, D-AgAu/S-CNT//GCE. The dealloying strategy of the designed sensor enhances the metallic active sites, causing rapid adsorption of Phe and a significantly higher effective area as compared to other modified electrodes. The steady-state oxidative signal of Phe at + 1.1&#xa0;V (vs Ag/AgCl) by i-t amperometry demonstrates two linear dependences in the concentration ranges, (5–1000) µM and (1000–2750) µM, exhibiting the limits of detection (LoD) as 0.5&#xa0;µM and 1.7&#xa0;µM at <i>S</i>/<i>N</i> = 3, respectively. Besides, the high selectivity of D-AgAu/S-CNT//GCE towards Phe disables the detection of other notable interferants, convincing the anti-interfering ability of the sensor. Certainly, the proposed sensor is subjected to the human serum sample for Phe determination, acquiring suitable recovery values. Overall, the high electrocatalytic properties establish the modified sensor to be dynamic and stable for further applications.</p> Graphical Abstract <p></p>

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Selective electrochemical detection of breast cancer biomarker on sulfur-doped CNT mediated dealloyed noble metal nanocomposite

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • Priyanka Pal,
  • Jayabrata Das

摘要

The inflation of breast cancer has been edging to increased cancer-associated morbidity and fatality over the years. The casualty of the detection of biomarkers often deters the proper treatment of the disease. This work discusses the facile alloy/dealloying process for electrochemical detection of the breast cancer biomarker, phenylalanine (Phe). The co-deposition of silver-gold (Ag-Au) alloy at a constant potential on the electrochemically deposited sulfur-doped carbon nanotubes (S-CNT//GCE), forming AgAu/S-CNT//GCE, is consecutively dealloyed to form a highly selective sensor, D-AgAu/S-CNT//GCE. The dealloying strategy of the designed sensor enhances the metallic active sites, causing rapid adsorption of Phe and a significantly higher effective area as compared to other modified electrodes. The steady-state oxidative signal of Phe at + 1.1 V (vs Ag/AgCl) by i-t amperometry demonstrates two linear dependences in the concentration ranges, (5–1000) µM and (1000–2750) µM, exhibiting the limits of detection (LoD) as 0.5 µM and 1.7 µM at S/N = 3, respectively. Besides, the high selectivity of D-AgAu/S-CNT//GCE towards Phe disables the detection of other notable interferants, convincing the anti-interfering ability of the sensor. Certainly, the proposed sensor is subjected to the human serum sample for Phe determination, acquiring suitable recovery values. Overall, the high electrocatalytic properties establish the modified sensor to be dynamic and stable for further applications.

Graphical Abstract