Electroanalytical determination of darunavir as antiretroviral drug by a sensor containing synthesized reduced graphene oxide
摘要
In this paper, a sensitive electroanalytical sensor by reduced graphene oxide (RGO) modified carbon paste electrode (CPE) was established for the determination of darunavir (DRV). For this goal, RGO was firstly prepared and recognized by different techniques. The oxidation potential of DRV was meaningfully decreased on the RGO/CPE surface versus CPE, and its anodic signal was amplified. In the optimal condition, the calibration curve for DRV was plotted from the DPV method. The linear dynamic ranges (LDR) and limit of detection (LOD) were achieved to be 0.5–900 µM and 0.41 µM, respectively. The diffusion coefficient and catalytic rate constant were calculated to be 1.02 × 10–5 cm2 s−1 and 8.4 × 106 cm3 mol−1 s−1, respectively. In addition, the practical presentation of RGO/CPE was performed by measuring the DRV in the tablet with good recovery. The suggested process is easy, cheap, and fast and might be utilized as a significant analytical tool in the quality control of the pharmaceutical production. It is worth mentioning that this study is the first to specifically address the electrochemical measurement of darunavir, making it novel in its field.