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Purpose <p>The objective of this study was to ascertain the actual benefits of regional analgesia in orthognathic surgery and to evaluate the influence of psychosocial factors on the outcomes.</p> Methods <p>This study assessed the efficacy of pre-emptive analgesic blocks in orthognathic surgery. The sample comprised 74 patients, who were randomly assigned to two groups. The first group, following the induction of general anesthesia, received maxillary and mandibular blocks with 0.5% levobupivacaine at a dosage of 5 ml per block. The second group served as the control group and received an equivalent volume of saline solution at the block injection sites. The primary hypothesis states that regional analgesia in orthognathic surgery enhances both intraoperative and postoperative analgesia. Various psychological questionnaires, pain scales, and postoperative recovery assessment tools were employed in the study. </p> Results <p>Participants who received the analgesic block required significantly fewer postoperative analgesics compared to those in the placebo group. Additionally, participants in the experimental group reported substantially lower Visual Analogue Scale (VAS) scores than those in the control group. Participants experiencing less intense pain reported a higher quality of recovery and an improved quality of life.</p> Conclusions <p> In conclusion, the administration of pre-emptive regional nerve blocks using 0.5% levobupivacaine has been demonstrated to be effective in reducing intraoperative analgesic requirements, minimizing postoperative pain, and limiting the need for postoperative analgesics.</p> <p>The study was registered at <a href="https://www.clinicaltrials.gov">www.clinicaltrials.gov</a> (registration No. NCT07133048, Principal Investigator: David Harmicar, registration date: August 19, 2025).</p>

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The true benefit of the regional block in orthognathic surgery lies in the preemptive effect

  • 期刊论文

  • 发表日期：

    2026年3月6日

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  • David Harmicar,
  • Margita Belušić,
  • Ana Goleš Juriša,
  • Željko Župan,
  • Arijan Zubović,
  • Robert Cerović

摘要

Purpose

The objective of this study was to ascertain the actual benefits of regional analgesia in orthognathic surgery and to evaluate the influence of psychosocial factors on the outcomes.

Methods

This study assessed the efficacy of pre-emptive analgesic blocks in orthognathic surgery. The sample comprised 74 patients, who were randomly assigned to two groups. The first group, following the induction of general anesthesia, received maxillary and mandibular blocks with 0.5% levobupivacaine at a dosage of 5 ml per block. The second group served as the control group and received an equivalent volume of saline solution at the block injection sites. The primary hypothesis states that regional analgesia in orthognathic surgery enhances both intraoperative and postoperative analgesia. Various psychological questionnaires, pain scales, and postoperative recovery assessment tools were employed in the study.

Results

Participants who received the analgesic block required significantly fewer postoperative analgesics compared to those in the placebo group. Additionally, participants in the experimental group reported substantially lower Visual Analogue Scale (VAS) scores than those in the control group. Participants experiencing less intense pain reported a higher quality of recovery and an improved quality of life.

Conclusions

In conclusion, the administration of pre-emptive regional nerve blocks using 0.5% levobupivacaine has been demonstrated to be effective in reducing intraoperative analgesic requirements, minimizing postoperative pain, and limiting the need for postoperative analgesics.

The study was registered at www.clinicaltrials.gov (registration No. NCT07133048, Principal Investigator: David Harmicar, registration date: August 19, 2025).