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Objective <p>To highlight the management of tongue cancer during pregnancy and provide a reference for all related specialties.</p> Study design <p>A case series of tongue cancer patients diagnosed during pregnancy. In addition, a PubMed Search and an analysis of the clinical, pathological, therapeutic, and oncological outcomes of all reported cases in the literature were performed.</p> Results <p>Fifty-four patients (including three from our center) were included in the study. The mean age at diagnosis was 30.94 years, and the median gestational age at diagnosis was 22 weeks. Overall, 62.5% of patients had T1-2 disease, and 56.2% were node-negative. In 40 events (72.7%), treatment was initiated during pregnancy, where upfront surgery was performed in 24 events (43.6%). Recurrence was reported in 16 events (29.1%), with a median interval to recurrence of 4.5 months (range: 1–24 months). Although maternal outcomes were poor, with 14 (25.9%) mortality, none died from the disease during pregnancy. The fetal outcomes were acceptable, with 42 (76.4%) healthy babies delivered.</p> Conclusion <p>Tongue cancer in pregnancy is a challenging clinical scenario that requires a case-by-case strategy within a multidisciplinary approach. Different treatment modalities are safe during pregnancy if appropriate precautions are taken. Despite the poor maternal outcome, the fetal outcomes are acceptable.</p>

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Tongue cancer in pregnancy: challenges and outcomes. A case series and review of the literature

  • 期刊论文

  • 发表日期：

    2025年12月26日

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  • Ahmed Abdallah,
  • Shadi Awny,
  • Islam H. Metwally,
  • Ahmed M. Eid,
  • Reem Ayman,
  • Randa Abdelaal,
  • Ransy Elhadidy,
  • Mariam Tarek,
  • Omar Hamdy

摘要

Objective

To highlight the management of tongue cancer during pregnancy and provide a reference for all related specialties.

Study design

A case series of tongue cancer patients diagnosed during pregnancy. In addition, a PubMed Search and an analysis of the clinical, pathological, therapeutic, and oncological outcomes of all reported cases in the literature were performed.

Results

Fifty-four patients (including three from our center) were included in the study. The mean age at diagnosis was 30.94 years, and the median gestational age at diagnosis was 22 weeks. Overall, 62.5% of patients had T1-2 disease, and 56.2% were node-negative. In 40 events (72.7%), treatment was initiated during pregnancy, where upfront surgery was performed in 24 events (43.6%). Recurrence was reported in 16 events (29.1%), with a median interval to recurrence of 4.5 months (range: 1–24 months). Although maternal outcomes were poor, with 14 (25.9%) mortality, none died from the disease during pregnancy. The fetal outcomes were acceptable, with 42 (76.4%) healthy babies delivered.

Conclusion

Tongue cancer in pregnancy is a challenging clinical scenario that requires a case-by-case strategy within a multidisciplinary approach. Different treatment modalities are safe during pregnancy if appropriate precautions are taken. Despite the poor maternal outcome, the fetal outcomes are acceptable.