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Purpose <p>To evaluate serum levels of the bone-formation-related markers sclerostin and alkaline phosphatase (ALP) in patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN), and to identify a correlation with radiographic findings.</p> Methods <p>A cross-sectional study was conducted with osteonecrosis patients [MRONJ (<i>n</i> = 11); ORN (<i>n</i> = 21)] compared with individuals without osteometabolic diseases (control group, CG <i>n</i> = 27). Serum levels of sclerostin (pg/ml) and ALP (U/L) were evaluated. Gray-level pixel intensity (mean-Mgv and standard deviation-SDgv), fractal dimension (FD), and lacunarity (Lac) in the necrotic site (N), at the perinecrotic bone (PB), and in the non-lesional-bone site (CB) were assessed.</p> Results <p>Higher sclerostin levels were observed in ORN (90, <i>p</i> = 0.04) and MRONJ (133, <i>p</i> &lt; 0.01) vs. CG (45). ALP differed (<i>p</i> &lt; 0.01) between MRONJ (60.2) and CG (79.3). All radiographic parameters revealed significant differences among the 3 sites (<i>p</i> &lt; 0.05). A multivariate analysis showed an association of sclerostin with Mgv at N (<i>p</i> = 0.002) and Lac (<i>p</i> &lt; 0.004) at CB, and an association of ALP with Mgv at N (<i>p</i> &lt; 0.01), SDgv at PB (<i>p</i> &lt; 0.01), and with sclerostin (<i>p</i> &lt; 0.01).</p> Conclusions <p>Serum sclerostin levels were higher in patients with osteonecrosis. ALP levels were lower in MRONJ patients than in CG. Both proteins were associated with each other and with radiographic findings.</p>

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Bone-formation-related markers in osteonecrosis of the jaws and their correlation with radiographic findings

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Riéli Elis Schulz,
  • Sandro Wopereis,
  • Juliana Lucena Schussel,
  • Laurindo Moacir Sassi,
  • Aira Maria Bonfim Santos,
  • Liliane Janete Grando,
  • Rogério Oliveira Gondak,
  • Gustavo Davi Rabelo

摘要

Purpose

To evaluate serum levels of the bone-formation-related markers sclerostin and alkaline phosphatase (ALP) in patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN), and to identify a correlation with radiographic findings.

Methods

A cross-sectional study was conducted with osteonecrosis patients [MRONJ (n = 11); ORN (n = 21)] compared with individuals without osteometabolic diseases (control group, CG n = 27). Serum levels of sclerostin (pg/ml) and ALP (U/L) were evaluated. Gray-level pixel intensity (mean-Mgv and standard deviation-SDgv), fractal dimension (FD), and lacunarity (Lac) in the necrotic site (N), at the perinecrotic bone (PB), and in the non-lesional-bone site (CB) were assessed.

Results

Higher sclerostin levels were observed in ORN (90, p = 0.04) and MRONJ (133, p < 0.01) vs. CG (45). ALP differed (p < 0.01) between MRONJ (60.2) and CG (79.3). All radiographic parameters revealed significant differences among the 3 sites (p < 0.05). A multivariate analysis showed an association of sclerostin with Mgv at N (p = 0.002) and Lac (p < 0.004) at CB, and an association of ALP with Mgv at N (p < 0.01), SDgv at PB (p < 0.01), and with sclerostin (p < 0.01).

Conclusions

Serum sclerostin levels were higher in patients with osteonecrosis. ALP levels were lower in MRONJ patients than in CG. Both proteins were associated with each other and with radiographic findings.