Scholarlink

Objectives <p>This study synthesized 4-formylphenyl acrylate (FA), capable of chemically binding to dentin collagen, and incorporated in-situ-synthesized antibacterial silver nanoparticles (NAg) to develop an experimental adhesive. The aim was to evaluate its antibacterial efficacy, bonding performance, and inhibitory effects on MMPs, offering a novel strategy to enhance dentin bonding stability.</p> Materials and methods <p>Silver nanoparticle dispersion was analyzed via scanning electron microscopy (SEM). Antibacterial activity was tested against <i>Streptococcus mutans</i> biofilm using MTT assay, colony forming units counting, live/dead staining, and SEM. Bonding performance was examined through micro-tensile bond strength tests (immediate and aged), failure mode analysis, and nanoleakage evaluation. Resin-dentin bonding interface was observed via SEM, and collagenase activity in the hybrid layer was quantified using in situ zymography.</p> Results <p>The FA-Ag adhesive group significantly inhibited the metabolic activity of S. mutans biofilm, reduced colony-forming units, improved micro-tensile bond strength, minimized nanoleakage, demonstrated well-formed bonding interface, and suppressed MMPs activity.</p> Conclusions <p>The FA-Ag-modified adhesive exhibits potent antibacterial properties, enhanced bond strength, and suppressed MMPs activity, making it a promising candidate for durable resin-dentin adhesion.</p> Clinical relevance <p>This FA-NAg adhesive system offers a multifunctional solution to enhance restoration longevity. It concurrently combats bacterial biofilm, strengthens dentin bonding, and inhibits enzymatic degradation, thereby addressing major causes of restoration failure such as secondary caries and interface deterioration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development of multifunctional dental adhesive with 4-formylphenyl acrylate and nano-silver

  • 期刊论文

  • 发表日期：

    2026年3月26日

查看全文
  • Qi Lin,
  • Lingkang Lin,
  • Huan Chen,
  • Zhengyuan Yang,
  • Xi He,
  • Song Zhu

摘要

Objectives

This study synthesized 4-formylphenyl acrylate (FA), capable of chemically binding to dentin collagen, and incorporated in-situ-synthesized antibacterial silver nanoparticles (NAg) to develop an experimental adhesive. The aim was to evaluate its antibacterial efficacy, bonding performance, and inhibitory effects on MMPs, offering a novel strategy to enhance dentin bonding stability.

Materials and methods

Silver nanoparticle dispersion was analyzed via scanning electron microscopy (SEM). Antibacterial activity was tested against Streptococcus mutans biofilm using MTT assay, colony forming units counting, live/dead staining, and SEM. Bonding performance was examined through micro-tensile bond strength tests (immediate and aged), failure mode analysis, and nanoleakage evaluation. Resin-dentin bonding interface was observed via SEM, and collagenase activity in the hybrid layer was quantified using in situ zymography.

Results

The FA-Ag adhesive group significantly inhibited the metabolic activity of S. mutans biofilm, reduced colony-forming units, improved micro-tensile bond strength, minimized nanoleakage, demonstrated well-formed bonding interface, and suppressed MMPs activity.

Conclusions

The FA-Ag-modified adhesive exhibits potent antibacterial properties, enhanced bond strength, and suppressed MMPs activity, making it a promising candidate for durable resin-dentin adhesion.

Clinical relevance

This FA-NAg adhesive system offers a multifunctional solution to enhance restoration longevity. It concurrently combats bacterial biofilm, strengthens dentin bonding, and inhibits enzymatic degradation, thereby addressing major causes of restoration failure such as secondary caries and interface deterioration.