Objective <p>Recently, the systematic review and meta-analysis “Epidemiological Trends in Enamel Hypomineralisation and Molar-Incisor Hypomineralisation: A Systematic Review and Meta-Analysis” was published in Clinical Oral Investigations. In 2025 a reader brought the omission of an epidemiological study from North America to the attention of the author group.</p> Materials and methods <p>After checking the eligibility for inclusion we aimed at updating the meta-analysis. After inclusion of this overlooked study the systematic review and meta-analysis covers 139 studies and data from a total of 199,999 participants.</p> Results <p>For North America, the MIH prevalence estimate decreased slightly from 0.239 (95% CI: 0.144–0.334) to 0.223 (95% CI: 0.140–0.306). Notably, the global prevalence estimate for MIH remained unchanged at 0.155 (95% CI: 0.144–0.166).</p> Conclusion <p>The addition of the overlooked study influenced slightly the MIH outcome for North America but had no impact on the previously drawn conclusions.</p> Clinical relevance <p>Enamel hypomineralisation/ Molar incisor hypomineralisation is prevalent across the globe and needs attention by dental practitioners.</p>

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Epidemiological trends in enamel hypomineralisation and molar-incisor hypomineralisation: a systematic review and meta-analysis

  • Nour Ammar,
  • Karl-Ferdinand Fresen,
  • Falk Schwendicke,
  • Jan Kühnisch

摘要

Objective

Recently, the systematic review and meta-analysis “Epidemiological Trends in Enamel Hypomineralisation and Molar-Incisor Hypomineralisation: A Systematic Review and Meta-Analysis” was published in Clinical Oral Investigations. In 2025 a reader brought the omission of an epidemiological study from North America to the attention of the author group.

Materials and methods

After checking the eligibility for inclusion we aimed at updating the meta-analysis. After inclusion of this overlooked study the systematic review and meta-analysis covers 139 studies and data from a total of 199,999 participants.

Results

For North America, the MIH prevalence estimate decreased slightly from 0.239 (95% CI: 0.144–0.334) to 0.223 (95% CI: 0.140–0.306). Notably, the global prevalence estimate for MIH remained unchanged at 0.155 (95% CI: 0.144–0.166).

Conclusion

The addition of the overlooked study influenced slightly the MIH outcome for North America but had no impact on the previously drawn conclusions.

Clinical relevance

Enamel hypomineralisation/ Molar incisor hypomineralisation is prevalent across the globe and needs attention by dental practitioners.