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Objective <p>Celiac disease (CD) is an immune-mediated chronic enteropathy that causes chronic inflammation and has been found to cause oral health problems. The aim of this study was to compare the levels of the inflammatory markers calcium (Ca), caspase-1 and tumor necrosis factor-alpha (TNF-<i>α</i>) in the gingival crevicular fluid (GCF) and saliva of patients with and without celiac disease.</p> Methods <p>A total of 60 participants were divided into two groups: patients with celiac disease on a gluten diet (C) (<i>n</i> = 30) and systemically healthy controls (H) (<i>n</i> = 30). Full-mouth periodontal measurements, including the gingival index (GI), plaque index (PI), bleeding on probing (BOP), and probing depth (PD), were recorded for all participants. Saliva and GCF samples were collected for analysis of the levels of TNF-<i>α</i>, Ca, and caspase-1 via enzyme-linked immunosorbent assay (ELISA).</p> Results <p>Salivary and GCF Ca, caspase-1, and TNF-α levels were not different between the two groups (<i>p</i> &gt; 0.05).</p> Conclusions <p>Oral inflammatory profiles of celiac disease patients on a gluten-free diet show similarities with systemically healthy individuals.</p>

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Inflammatory parameters in gingival crevicular fluid and saliva of patients with celiac disease: a comparative analysis

  • 期刊论文

  • 发表日期：

    2025年10月28日

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  • Arife Sabancı,
  • Ömer Alperen Kırmızıgül,
  • Nazmi Özgen,
  • Halil İbrahim Sabancı,
  • Ahmet Koç,
  • Faruk Dişli,
  • Sedat Yıldız,
  • Kübra Aral

摘要

Objective

Celiac disease (CD) is an immune-mediated chronic enteropathy that causes chronic inflammation and has been found to cause oral health problems. The aim of this study was to compare the levels of the inflammatory markers calcium (Ca), caspase-1 and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) and saliva of patients with and without celiac disease.

Methods

A total of 60 participants were divided into two groups: patients with celiac disease on a gluten diet (C) (n = 30) and systemically healthy controls (H) (n = 30). Full-mouth periodontal measurements, including the gingival index (GI), plaque index (PI), bleeding on probing (BOP), and probing depth (PD), were recorded for all participants. Saliva and GCF samples were collected for analysis of the levels of TNF-α, Ca, and caspase-1 via enzyme-linked immunosorbent assay (ELISA).

Results

Salivary and GCF Ca, caspase-1, and TNF-α levels were not different between the two groups (p > 0.05).

Conclusions

Oral inflammatory profiles of celiac disease patients on a gluten-free diet show similarities with systemically healthy individuals.