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<p>Mechanism of action (MoA) studies on the cytotoxic thiolato-bridged triosmium carbonyl clusters Os<sub>3</sub>(CO)<sub>10</sub>(μ-H)(μ-SR) (<b>2</b>) indicates that their cytotoxicity is associated with increased reactive oxygen species (ROS) generation, G<sub>2</sub>/M cell cycle arrest, and subsequent apoptosis. Cellular uptake is a key factor, with an increased reactivity of the cluster with serum leading to reduced available concentrations in the medium thereby diminishing its anti-proliferative effect. Reactivity studies reveal that biomolecular interactions occur predominantly at the triosmium core, with a preference for amine-containing species.</p>

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Decoding the mechanism for cytotoxicity in thiolato-bridged triosmium carbonyl clusters: from serum reactivity to cellular impact

  • 期刊论文

  • 发表日期：

    2025年10月17日

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  • Xin Liang,
  • Hélène C. Bertrand,
  • Nicolas Delsuc,
  • Bohong Huang,
  • Weng Kee Leong,
  • Alvaro Lopez-Sanchez

摘要

Mechanism of action (MoA) studies on the cytotoxic thiolato-bridged triosmium carbonyl clusters Os3(CO)10(μ-H)(μ-SR) (2) indicates that their cytotoxicity is associated with increased reactive oxygen species (ROS) generation, G2/M cell cycle arrest, and subsequent apoptosis. Cellular uptake is a key factor, with an increased reactivity of the cluster with serum leading to reduced available concentrations in the medium thereby diminishing its anti-proliferative effect. Reactivity studies reveal that biomolecular interactions occur predominantly at the triosmium core, with a preference for amine-containing species.