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<p>New organotin(IV) mono- and bis-carboxylate complexes derivatives of Bexarotene (bex), viz. R<sub>3</sub>Sn(bex) (where R = Ph (<b>1</b>); Cy (<b>2</b>); nBu (<b>3</b>)), and R<sub>2</sub>Sn(bex)<sub>2</sub> (where R = Et (<b>4</b>), tBu (<b>5</b>), Ph (<b>6</b>)) were synthesized. Compounds were fully characterized using spectroscopic techniques. The molecular structure for the Ph<sub>3</sub>Sn(bex) (<b>1</b>) in crystalline form was established by single-crystal X-ray diffraction. Electrochemical properties of tin complexes and bexarotene were investigated by cyclic voltammetry. The target compounds are characterized by the high oxidation potentials in the mixture of aprotic solvents. The anti/prooxidant activity of the complexes and bexarotene in the lipid peroxidation process and in the reaction of the DNA oxidative damage was studied in vitro. Excellent cell growth inhibition against A549, HCT 116 and MCF-7 cancer cells was observed for triorganotin (IV) carboxylates with IC<sub>50</sub> values mostly under the submicromolar concentration range and there are more effective than bexarotene or cisplatin.</p> Graphical abstract <p></p>

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Organotin(IV) carboxylates—derivatives of bexarotene: synthesis, characterization, anti/prooxidant activity, and high cytotoxicity

  • 期刊论文

  • 发表日期：

    2025年6月4日

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  • D. A. Burmistrova,
  • N. P. Pomortseva,
  • N. T. Berberova,
  • N. R. Almyasheva,
  • M. A. Kiskin,
  • A. I. Poddel’sky,
  • A. S. Vashurin,
  • I. V. Smolyaninov

摘要

New organotin(IV) mono- and bis-carboxylate complexes derivatives of Bexarotene (bex), viz. R3Sn(bex) (where R = Ph (1); Cy (2); nBu (3)), and R2Sn(bex)2 (where R = Et (4), tBu (5), Ph (6)) were synthesized. Compounds were fully characterized using spectroscopic techniques. The molecular structure for the Ph3Sn(bex) (1) in crystalline form was established by single-crystal X-ray diffraction. Electrochemical properties of tin complexes and bexarotene were investigated by cyclic voltammetry. The target compounds are characterized by the high oxidation potentials in the mixture of aprotic solvents. The anti/prooxidant activity of the complexes and bexarotene in the lipid peroxidation process and in the reaction of the DNA oxidative damage was studied in vitro. Excellent cell growth inhibition against A549, HCT 116 and MCF-7 cancer cells was observed for triorganotin (IV) carboxylates with IC50 values mostly under the submicromolar concentration range and there are more effective than bexarotene or cisplatin.

Graphical abstract