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<p>Peripheral arterial occlusive disease (PAOD) is the manifestation of arteriosclerosis in the arteries supplying the legs and arms. It presents as a&#xa0;marker or hallmark disease for arteriosclerotic changes in other vascular regions. Arteriosclerosis is usually manifested in higher age. Risk factors, such as diabetes mellitus, arterial hypertension, nicotine abuse or disorders of lipid metabolism can cause the disease to be manifested at a&#xa0;younger age and lead to a&#xa0;progressive course. Epidemiological data show that diabetes mellitus in particular coexists in patients with intermittent claudication or critical limb ischemia. Patients with PAOD who also suffer from diabetes mellitus have a&#xa0;poor prognosis because they have a&#xa0;higher amputation rate and are also at greater risk of arteriosclerotic comorbidities. Both the higher amputation rate and the comorbidity increase the mortality risk of patients with PAOD who also have diabetes mellitus. It is therefore important to detect and treat PAOD early in diabetics. Consistent adjustment of all risk factors and consistent use of medication in secondary prophylaxis result in a&#xa0;significant reduction in the risk of amputations, cardiovascular events and mortality. Unfortunately, current epidemiological studies show that secondary prophylaxis is underrepresented in patients with PAOD. Because of the relevance of diabetes mellitus in relation to the prognosis of arteriosclerotic disease, this article emphasizes the importance of basic diagnostic and therapeutic measures in patients with PAOD.</p>

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Spezielle Relevanz des Diabetes mellitus bei Patienten mit peripherer arterieller Verschlusserkrankung

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Jürgen Jahn

摘要

Peripheral arterial occlusive disease (PAOD) is the manifestation of arteriosclerosis in the arteries supplying the legs and arms. It presents as a marker or hallmark disease for arteriosclerotic changes in other vascular regions. Arteriosclerosis is usually manifested in higher age. Risk factors, such as diabetes mellitus, arterial hypertension, nicotine abuse or disorders of lipid metabolism can cause the disease to be manifested at a younger age and lead to a progressive course. Epidemiological data show that diabetes mellitus in particular coexists in patients with intermittent claudication or critical limb ischemia. Patients with PAOD who also suffer from diabetes mellitus have a poor prognosis because they have a higher amputation rate and are also at greater risk of arteriosclerotic comorbidities. Both the higher amputation rate and the comorbidity increase the mortality risk of patients with PAOD who also have diabetes mellitus. It is therefore important to detect and treat PAOD early in diabetics. Consistent adjustment of all risk factors and consistent use of medication in secondary prophylaxis result in a significant reduction in the risk of amputations, cardiovascular events and mortality. Unfortunately, current epidemiological studies show that secondary prophylaxis is underrepresented in patients with PAOD. Because of the relevance of diabetes mellitus in relation to the prognosis of arteriosclerotic disease, this article emphasizes the importance of basic diagnostic and therapeutic measures in patients with PAOD.