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<p>Saxagliptin (Onglyza) is an inhibitor of dipeptidyl peptidase-4 (DPP-4) type 2 diabetes can be treated with this drug. Unremitting diabetes is characterized by elevated blood sugar levels. Saxagliptin is one example of an antidiabetic medication that lowers blood glucose levels. The compound saxagliptin have been distinguished and measured by the utilize of analytical and bioanalytical methods including reverse phase high performance, ultrahigh performance chromatographic, and spectroscopic approaches. Assessment of the pharmacokinetic characteristics, bioavailability, and metabolism of this antidiabetic pharmaceutical in biological matrices has too profited significantly from the application of bioanalytical approaches. The recognizable proof and evaluation of saxagliptin was affirmed through the utilize of analytical and bioanalytical methods, such as HPLC, HPTLC, UPLC, RP-HPLC, UV spectroscopy, UV–VIS spectroscopy, capillary electrophoresis, LC/MS, RP-LC-PDA, UPLC-MS, UHPLC, LC–ESI–MS, RPHPLC-UV, LC–MS/MS, HILIC-MS, SPE-LC-UV. An outline of the characteristics and traits of antidiabetic medicine saxagliptin is displayed in this work, in conjunction with the analytical and bioanalytical strategies utilized to distinguish and evaluate them.</p>

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Comprehensive review on saxagliptin: properties, characteristics, analytical methods and bio-analytical methods

  • 期刊论文

  • 发表日期：

    2025年8月12日

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  • Anusha Gandi,
  • Sandhya Mojjada,
  • Manasa Puttagunta,
  • Sai Sreevani Manikyam,
  • Varaprasada Rao Kollabathula,
  • Srinivasa Rao Yaraguntla

摘要

Saxagliptin (Onglyza) is an inhibitor of dipeptidyl peptidase-4 (DPP-4) type 2 diabetes can be treated with this drug. Unremitting diabetes is characterized by elevated blood sugar levels. Saxagliptin is one example of an antidiabetic medication that lowers blood glucose levels. The compound saxagliptin have been distinguished and measured by the utilize of analytical and bioanalytical methods including reverse phase high performance, ultrahigh performance chromatographic, and spectroscopic approaches. Assessment of the pharmacokinetic characteristics, bioavailability, and metabolism of this antidiabetic pharmaceutical in biological matrices has too profited significantly from the application of bioanalytical approaches. The recognizable proof and evaluation of saxagliptin was affirmed through the utilize of analytical and bioanalytical methods, such as HPLC, HPTLC, UPLC, RP-HPLC, UV spectroscopy, UV–VIS spectroscopy, capillary electrophoresis, LC/MS, RP-LC-PDA, UPLC-MS, UHPLC, LC–ESI–MS, RPHPLC-UV, LC–MS/MS, HILIC-MS, SPE-LC-UV. An outline of the characteristics and traits of antidiabetic medicine saxagliptin is displayed in this work, in conjunction with the analytical and bioanalytical strategies utilized to distinguish and evaluate them.