Background <p>Hepatobiliary cancers are tumors with hepatocellular (hepatocellular carcinoma), biliary (cholangiocarcinoma), or hepatocellular–biliary (combined hepatocellular and cholangiocarcinoma) differentiation. They are relatively rare in Germany compared to other cancers of the digestive tract but are among the most common causes of cancer-related deaths worldwide, as they are usually diagnosed at an advanced stage and are associated with a&#xa0;poor prognosis.</p> Objective <p>The aim of this article is to provide an overview of the current status of hepatobiliary cancer in terms of epidemiology, pathology, and molecular pathology, taking into account currently valid classifications and guidelines.</p> Results <p>Hepatobiliary cancers differ not only histologically within the individual tumor entities but also exhibit specific molecular changes that are relevant for prognosis and targeted therapies.</p>