Scholarlink

Background <p>Testicular germ cell tumors are the most common type of cancer in young men (aged 15–44). The majority of these patients have an excellent prognosis.</p> Objectives <p>The aim of this study is to describe the incidence and survival of male germ cell tumors based on nationally available population-based cancer registry data.</p> Materials and methods <p>We included all patients with germ cell tumors of the testis registered in German population-based cancer registries between 2009 and 2023. Histological classification was then performed according to the World Health Organization classification. The crude and age-standardized incidence (old European standard) as well as the absolute and relative 5‑year survival for the entire period were stratified according to histology, T‑status, and stage (I:&#xa0;localized, II: lymph node metastasis, III: distant metastasis).</p> Results <p>A&#xa0;total of 56,735 cases were registered, of which 65.3% were seminomas, 34.0% were nonseminomatous tumors, and 0.6% were spermatocytic tumors. Within the group of nonseminomatous tumors, mixed tumors (51.8%) and embryonal cell carcinomas (27.3%) were the most common entities. Furthermore, 83.7% of tumors were diagnosed as T1–T2 tumors and 75.2% of tumors were diagnosed at stage&#xa0;I. The crude incidence rate of germ cell tumors was 93.5 per million person–years (age-standardized: 94.8). The absolute 5‑year survival probability was 95.8% (relative survival 97.4%). Patients with spermatocytic tumors showed no excess mortality (relative survival 101.7%), while patients with choriocarcinoma showed the worst survival (relative survival: 70.4%). Stage&#xa0;I patients had a&#xa0;relative survival of 99.4%.</p> Conclusion <p>Future research on testicular germ cell tumors should focus on minimizing the short- and long-term sequelae, precisely because of the excellent survival probabilities. In the case of the very rare entity of choriocarcinomas, which have a&#xa0;markedly poorer prognosis, there is a&#xa0;need to develop more effective therapies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Inzidenz und relatives Überleben von Patienten mit Keimzelltumoren der Hoden in Deutschland

  • 期刊论文

  • 发表日期：

    2026年2月10日

查看全文
  • Andreas Stang,
  • Ina Wellmann,
  • Sylke Zeißig,
  • Hiltraud Kajüter,
  • Alexander Katalinic,
  • Alice Nennecke,
  • Eunice Sirri,
  • Sabine Luttmann,
  • Andreas Stang,
  • Soo-Zin Kim-Wanner,
  • Christina Justenhoven,
  • Bernd Holleczek,
  • Volker Arndt,
  • Jacqueline Müller-Nordhorn,
  • Kerstin Weitmann,
  • Alexander Kluttig,
  • Renate Kirschner-Schwabe,
  • Antje Niedostatek,
  • Astrid Heßmer,
  • Desiree Grabow

摘要

Background

Testicular germ cell tumors are the most common type of cancer in young men (aged 15–44). The majority of these patients have an excellent prognosis.

Objectives

The aim of this study is to describe the incidence and survival of male germ cell tumors based on nationally available population-based cancer registry data.

Materials and methods

We included all patients with germ cell tumors of the testis registered in German population-based cancer registries between 2009 and 2023. Histological classification was then performed according to the World Health Organization classification. The crude and age-standardized incidence (old European standard) as well as the absolute and relative 5‑year survival for the entire period were stratified according to histology, T‑status, and stage (I: localized, II: lymph node metastasis, III: distant metastasis).

Results

A total of 56,735 cases were registered, of which 65.3% were seminomas, 34.0% were nonseminomatous tumors, and 0.6% were spermatocytic tumors. Within the group of nonseminomatous tumors, mixed tumors (51.8%) and embryonal cell carcinomas (27.3%) were the most common entities. Furthermore, 83.7% of tumors were diagnosed as T1–T2 tumors and 75.2% of tumors were diagnosed at stage I. The crude incidence rate of germ cell tumors was 93.5 per million person–years (age-standardized: 94.8). The absolute 5‑year survival probability was 95.8% (relative survival 97.4%). Patients with spermatocytic tumors showed no excess mortality (relative survival 101.7%), while patients with choriocarcinoma showed the worst survival (relative survival: 70.4%). Stage I patients had a relative survival of 99.4%.

Conclusion

Future research on testicular germ cell tumors should focus on minimizing the short- and long-term sequelae, precisely because of the excellent survival probabilities. In the case of the very rare entity of choriocarcinomas, which have a markedly poorer prognosis, there is a need to develop more effective therapies.