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Background <p>Malignant wounds are a&#xa0;clinically highly relevant issue in 5–14% of patients with advanced malignancies. They are associated with exudation, pain, bleeding, malodor, and pruritus as well as considerable functional and psychosocial impairment and require interdisciplinary symptom management.</p> Objective <p>This article aims to delineate the role of external beam radiotherapy within the palliative care concept for malignant wounds and to summarize fractionation and application concepts that have proven effective in clinical practice.</p> Results <p>Despite a&#xa0;predominantly retrospective evidence base, cohort studies demonstrate high symptom control rates of &gt; 80%, with an overall very favorable safety profile. Hypofractionated regimens (e.g., 20 Gy in 5&#xa0;fractions, 30 Gy in 10&#xa0;fractions, 8 Gy in a&#xa0;single fraction) are particularly suitable for rapid hemostasis and symptom relief in patients with a&#xa0;limited prognosis, whereas conventionally fractionated regimens of ≥ 30 Gy may be considered for more durable control of exulcerated lesions.</p> Conclusion <p>Clinical experience and case series underscore the potential of external beam radiotherapy to achieve rapid and clinically meaningful improvements in quality of life. Radiotherapeutic options should therefore not be reserved for a&#xa0;last resort but rather integrated early into palliative oncologic treatment pathways in cases of impending or early ulceration and be systematically further evaluated in prospective studies.</p>

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Strahlentherapie maligner Wunden: schnelle und effektive Symptomlinderung

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Felix Bock

摘要

Background

Malignant wounds are a clinically highly relevant issue in 5–14% of patients with advanced malignancies. They are associated with exudation, pain, bleeding, malodor, and pruritus as well as considerable functional and psychosocial impairment and require interdisciplinary symptom management.

Objective

This article aims to delineate the role of external beam radiotherapy within the palliative care concept for malignant wounds and to summarize fractionation and application concepts that have proven effective in clinical practice.

Results

Despite a predominantly retrospective evidence base, cohort studies demonstrate high symptom control rates of > 80%, with an overall very favorable safety profile. Hypofractionated regimens (e.g., 20 Gy in 5 fractions, 30 Gy in 10 fractions, 8 Gy in a single fraction) are particularly suitable for rapid hemostasis and symptom relief in patients with a limited prognosis, whereas conventionally fractionated regimens of ≥ 30 Gy may be considered for more durable control of exulcerated lesions.

Conclusion

Clinical experience and case series underscore the potential of external beam radiotherapy to achieve rapid and clinically meaningful improvements in quality of life. Radiotherapeutic options should therefore not be reserved for a last resort but rather integrated early into palliative oncologic treatment pathways in cases of impending or early ulceration and be systematically further evaluated in prospective studies.