<p>The urothelial carcinoma of the bladder (UC) is among the most common malignant tumors of the urinary tract and poses a&#xa0;significant challenge in uro-oncological care. Despite modern treatment options, such as surgical removal of the bladder and innovative systemic therapies, the prognosis in advanced disease stages remains difficult. In addition to medical aspects, psychosocial burdens on patients are increasingly important. The diagnosis, invasive therapies, risk of recurrence, and uncertainty regarding disease progression often lead to psychological stress, anxiety, and depression, which negatively impact quality of life and treatment motivation. Psychosocial support and psycho-oncological interventions are therefore integral components of comprehensive care. Screening tools, individual counseling, psychoeducational measures, and specific programs for stoma management and sexuality help reduce fears, strengthen resources, and promote resilience. An interdisciplinary collaboration between urologists, psycho-oncologists, social workers, and physiotherapists is essential to meet the diverse needs of patients. Current research shows that structured psycho-oncological interventions improve psychological stability, reduce depressive symptoms, and significantly enhance quality of life. Innovative approaches such as telemedicine and online support groups offer flexible access to psychosocial services, especially for older and mobility-impaired patients. Despite progress, gaps remain in the evidence base, particularly regarding long-term effects and individualized interventions. Future developments should focus on personalized, evidence-based strategies and the use of digital technologies to ensure sustainable improvements in psychosocial care. Political support and standardization of care structures are necessary to comprehensively address the needs of affected individuals and to sustainably improve their quality of life.</p>