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<p>Soft tissue sarcomas are rare, heterogeneous tumors predominantly located in the extremities. Diagnostic work-up includes contrast-enhanced magnetic resonance imaging (MRI) and usually a&#xa0;biopsy that should be performed at the center responsible for definitive resection. The primary therapeutic goal is wide resection of the tumor (R0 resection), as positive margins (R1 or R2 resections) are associated with increased recurrence and mortality. Due to interdisciplinary treatment approaches, in most cases, limb-sparing surgery is possible. Most patients receive neoadjuvant or adjuvant radiotherapy. Depending on the type of tumor, neoadjuvant or adjuvant chemotherapy is carried out. Isolated limb perfusion may be considered in selected cases. Management should be centralized in sarcoma centers, as this significantly improves survival. Structured follow-up is essential to detect local recurrences or metastases early.</p>

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Diagnostik und operative Therapie von Weichteilsarkomen der Extremitäten

  • 期刊论文

  • 发表日期：

    2025年8月14日

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  • Jakob Bollmann,
  • Julian Deisenhofer,
  • Burkhard Lehner

摘要

Soft tissue sarcomas are rare, heterogeneous tumors predominantly located in the extremities. Diagnostic work-up includes contrast-enhanced magnetic resonance imaging (MRI) and usually a biopsy that should be performed at the center responsible for definitive resection. The primary therapeutic goal is wide resection of the tumor (R0 resection), as positive margins (R1 or R2 resections) are associated with increased recurrence and mortality. Due to interdisciplinary treatment approaches, in most cases, limb-sparing surgery is possible. Most patients receive neoadjuvant or adjuvant radiotherapy. Depending on the type of tumor, neoadjuvant or adjuvant chemotherapy is carried out. Isolated limb perfusion may be considered in selected cases. Management should be centralized in sarcoma centers, as this significantly improves survival. Structured follow-up is essential to detect local recurrences or metastases early.