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<p>Paraneoplastic neurological syndromes (PNS) encompass various disorders of the central, peripheral, and autonomic nervous systems, as well as neuromuscular transmission and muscles. They are associated with disease development through an immune response, both against tumor tissue (defense against cancer) and against the body’s own neural tissue (autoimmune reaction). Psychiatric manifestations, including affective symptoms (such as mood lability, depression, and anxiety), cognitive impairments (such as attention, memory, and language), psychotic symptoms (such as hallucinations and loss of touch with reality), and personality and behavioral changes, must be considered in the diagnosis of PNS, particularly when the limbic network is involved. Early diagnosis is crucial for both neurological and oncological outcomes, especially in high-risk PNS. This article discusses clinical syndromes, pathophysiology, and classification, examines the clinical spectrum and clinical significance of psychiatric symptoms in peripheral nervous system disorders (PNS), and outlines treatment options.</p>

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Psychiatrische Symptome bei „high risk“ paraneoplastischen neurologischen Syndromen

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月9日

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  • Stefan Oberndorfer,
  • Markus Hutterer

摘要

Paraneoplastic neurological syndromes (PNS) encompass various disorders of the central, peripheral, and autonomic nervous systems, as well as neuromuscular transmission and muscles. They are associated with disease development through an immune response, both against tumor tissue (defense against cancer) and against the body’s own neural tissue (autoimmune reaction). Psychiatric manifestations, including affective symptoms (such as mood lability, depression, and anxiety), cognitive impairments (such as attention, memory, and language), psychotic symptoms (such as hallucinations and loss of touch with reality), and personality and behavioral changes, must be considered in the diagnosis of PNS, particularly when the limbic network is involved. Early diagnosis is crucial for both neurological and oncological outcomes, especially in high-risk PNS. This article discusses clinical syndromes, pathophysiology, and classification, examines the clinical spectrum and clinical significance of psychiatric symptoms in peripheral nervous system disorders (PNS), and outlines treatment options.