Scholarlink

<p>Creutzfeldt–Jakob disease is a&#xa0;rare, rapidly progressing prion disease. We report the case of a&#xa0;man with atypical neurological clinical presentation. He presented with problems of swallowing and speaking, weight loss, and extrapyramidal symptoms. Other neurodegenerative diseases, such as motor neuron disease or Parkinson’s syndrome were considered; we also excluded different causes of encephalitis. Additional diagnostics with cerebral MRI, EEG, and lumbar puncture confirmed the suspected diagnosis of Creutzfeldt-–Jakob disease. The final detection of pathological prion proteins was conducted with RT-QuIC assay. The neuropathological autopsy verified the final diagnosis of a&#xa0;spongiform encephalopathy, i.e., Creutzfeldt–Jakob disease.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Creutzfeldt-Jakob-Erkrankung mit atypischer Präsentation

  • 期刊论文

  • 发表日期：

    2025年2月27日

查看全文
  • Ines Spazierer

摘要

Creutzfeldt–Jakob disease is a rare, rapidly progressing prion disease. We report the case of a man with atypical neurological clinical presentation. He presented with problems of swallowing and speaking, weight loss, and extrapyramidal symptoms. Other neurodegenerative diseases, such as motor neuron disease or Parkinson’s syndrome were considered; we also excluded different causes of encephalitis. Additional diagnostics with cerebral MRI, EEG, and lumbar puncture confirmed the suspected diagnosis of Creutzfeldt-–Jakob disease. The final detection of pathological prion proteins was conducted with RT-QuIC assay. The neuropathological autopsy verified the final diagnosis of a spongiform encephalopathy, i.e., Creutzfeldt–Jakob disease.