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Introduction <p>Glaucoma is one of the leading causes of irreversible blindness, posing a&#xa0;growing global challenge. Trabeculectomy (TE) remains the gold standard in glaucoma surgery, while alternative procedures such as the PreserFlo MicroShunt (PF; Santen Inc., Osaka, Japan) have a&#xa0;lower risk profile and offer comparable intraocular pressure (IOP) reduction.</p> Methods <p>This retrospective study analyzed 204 eyes of patients undergoing either trabeculectomy or PreserFlo implantation. The primary endpoint was the change in IOP, while secondary endpoints included postoperative complications, needling rates, and revision procedures. Data were collected over 1&#xa0;year for statistical analysis.</p> Results <p>Both procedures resulted in significant IOP reduction and stabilization of the peripapillary retinal nerve fiber layer (RNFL). Postoperative hypotony was more common after trabeculectomy at 1&#xa0;week (TE: 22.2% vs. PF: 16.3%), while needling interventions were more frequent with PreserFlo (PF: 52.5% vs. TE: 35.9%). No significant difference in long-term IOP control was observed.</p> Conclusion <p>Both trabeculectomy and the PreserFlo MicroShunt are effective for IOP control. PreserFlo has a&#xa0;lower risk of postoperative complications but requires more frequent additional interventions. These findings highlight the importance of individualized treatment decisions based on patient-specific factors.</p>

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PreserFlo MicroShunt vs. trabeculectomy in patients with uncontrolled glaucoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月10日

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  • Lukas Höflechner,
  • Thomas Falb,
  • Lena Haiden,
  • Andreas Guttmann,
  • Wolfgang List,
  • Astrid Heidinger,
  • Lukas Keintzel,
  • Fabian Wallisch,
  • Manuel Großpoetzl,
  • Regina Riedl,
  • Ewald Lindner

摘要

Introduction

Glaucoma is one of the leading causes of irreversible blindness, posing a growing global challenge. Trabeculectomy (TE) remains the gold standard in glaucoma surgery, while alternative procedures such as the PreserFlo MicroShunt (PF; Santen Inc., Osaka, Japan) have a lower risk profile and offer comparable intraocular pressure (IOP) reduction.

Methods

This retrospective study analyzed 204 eyes of patients undergoing either trabeculectomy or PreserFlo implantation. The primary endpoint was the change in IOP, while secondary endpoints included postoperative complications, needling rates, and revision procedures. Data were collected over 1 year for statistical analysis.

Results

Both procedures resulted in significant IOP reduction and stabilization of the peripapillary retinal nerve fiber layer (RNFL). Postoperative hypotony was more common after trabeculectomy at 1 week (TE: 22.2% vs. PF: 16.3%), while needling interventions were more frequent with PreserFlo (PF: 52.5% vs. TE: 35.9%). No significant difference in long-term IOP control was observed.

Conclusion

Both trabeculectomy and the PreserFlo MicroShunt are effective for IOP control. PreserFlo has a lower risk of postoperative complications but requires more frequent additional interventions. These findings highlight the importance of individualized treatment decisions based on patient-specific factors.