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<p>Thiazole derivative molecules possess versatile functions such as potential pharmacological activity. In this study, we synthesized a new set of thiazole–hydrazone–butyl lactone hybrids. These novel hybrid compounds were efficiently synthesized aiming to obtain novel hybrids and candidate drug molecules with likely biological activities. The structures of the synthesized thiazole–hydrazone–butyl lactone hybrids were characterized by NMR and FT-IR spectroscopic methods. Besides, the potential of these novel molecules as the inducers or inhibitors of pyroptosis, a pro-inflammatory cell death mechanism, were studied in ovarian granulosa cells (KGN cell line) in vitro, for the first time. The data from ELISA experiments showed that some of these compounds led to increases in the levels of both IL-18 and LDH&#xa0;(pro-inflammatory molecules) released from these cells. In contrast, the treatment of granulosa cells with some other compounds resulted in decreases in the levels of both IL-18 and LDH released to the extracellular space. Combined, it can be proposed that these novel thiazole–hydrazone–butyl lactone hybrids might be able to modulate pyroptotic cell death in granulosa cells in vitro. The mechanistic details of thiazole–hydrazone–butyl lactone hybrid molecule-mediated pro-inflammatory cell death in granulosa cells need to be identified in further studies, by also performing <i>in vivo</i> experiments.</p> Graphical abstract <p></p>

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New thiazole–hydrazone–butyl lactone hybrid molecules: their synthesis, characterization, and preliminary data on their effects on the release of pro-inflammatory proteins from granulosa cells in vitro

  • 期刊论文

  • 发表日期：

    2026年7月4日

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  • Aysegül Nazli Özcan,
  • Meliha Burcu Gürdere,
  • Caglar Berkel,
  • Oguz Özbek,
  • Sukran Yagmur Avcioglu

摘要

Thiazole derivative molecules possess versatile functions such as potential pharmacological activity. In this study, we synthesized a new set of thiazole–hydrazone–butyl lactone hybrids. These novel hybrid compounds were efficiently synthesized aiming to obtain novel hybrids and candidate drug molecules with likely biological activities. The structures of the synthesized thiazole–hydrazone–butyl lactone hybrids were characterized by NMR and FT-IR spectroscopic methods. Besides, the potential of these novel molecules as the inducers or inhibitors of pyroptosis, a pro-inflammatory cell death mechanism, were studied in ovarian granulosa cells (KGN cell line) in vitro, for the first time. The data from ELISA experiments showed that some of these compounds led to increases in the levels of both IL-18 and LDH (pro-inflammatory molecules) released from these cells. In contrast, the treatment of granulosa cells with some other compounds resulted in decreases in the levels of both IL-18 and LDH released to the extracellular space. Combined, it can be proposed that these novel thiazole–hydrazone–butyl lactone hybrids might be able to modulate pyroptotic cell death in granulosa cells in vitro. The mechanistic details of thiazole–hydrazone–butyl lactone hybrid molecule-mediated pro-inflammatory cell death in granulosa cells need to be identified in further studies, by also performing in vivo experiments.

Graphical abstract