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<p>Palladium-catalyzed carbonylation of 6-bromo[1,3]oxazolo[4,5-<i>b</i>]pyridines was investigated. The direction of this reaction depends on the C2-substituents on the oxazole ring. The new derivatives of methyl [1,3]oxazolo[4,5-<i>b</i>]pyridine-6-carboxylate and [1,3]oxazolo[4,5-<i>b</i>]pyridine-6-carboxylic acid have been synthesized by ring-closure reaction of methyl 6-amino-5-hydroxynicotinate or 6-amino-5-hydroxynicotinic acid.</p> Graphical Abstract <p></p>

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Palladium-catalyzed carbonylation of 6-bromo[1,3]oxazolo[4,5-b]pyridines. Synthesis of methyl [1,3]oxazolo[4,5-b]pyridine-6-carboxylates and [1,3]oxazolo[4,5-b]pyridine-6-carboxylic acids

  • 期刊论文

  • 发表日期：

    2026年7月2日

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  • Andrey S. Tolkunov,
  • Valery S. Tolkunov,
  • Olga V. Smirnova,
  • Sergey V. Tolkunov

摘要

Palladium-catalyzed carbonylation of 6-bromo[1,3]oxazolo[4,5-b]pyridines was investigated. The direction of this reaction depends on the C2-substituents on the oxazole ring. The new derivatives of methyl [1,3]oxazolo[4,5-b]pyridine-6-carboxylate and [1,3]oxazolo[4,5-b]pyridine-6-carboxylic acid have been synthesized by ring-closure reaction of methyl 6-amino-5-hydroxynicotinate or 6-amino-5-hydroxynicotinic acid.

Graphical Abstract