Synthesis of new amino(phenylsulfonyl)dihydropyrido[2,3-d]pyrimidinedione derivatives using Fe3O4@vitamin B1 as a nanocatalyst
摘要
New amino(phenylsulfonyl)dihydropyrido[2,3-d]pyrimidinedione derivatives were synthesized using a three-component reaction involving the starting materials aryl aldehydes, (phenylsulfonyl)acetonitrile, and 6-aminouracil or 6-amino-1,3-dimethyluracil in the presence of a Fe3O4@vitamin B1 nanocatalyst. The present method was very efficient and synthesized various amino(phenylsulfonyl)dihydropyrido[2,3-d]pyrimidinedione derivatives in a short reaction times and with good yields. Green solvent, high yield of products, easy separation and purification, and synthesis of various dihydropyrido[2,3-d]pyrimidinedione derivatives are the advantages of the present work. In work-up procedure, the Fe3O4@vitamin B1 nanocatalyst was simply separated from the reaction medium by an external magnet and reused for similar reactions without losing catalytic properties.
Graphical Abstract