<p>In this study, an attempt has been made to present a new design for the synthesis of various pyridine derivatives with imidate and amidine substitutions using available starting materials. These results are interesting in heterocyclic chemistry for the synthesis of 4-amino-5-cyano-6-(cyanomethyl)-pyridine-imidamide (imidate) in good yields (70–92%), via the four-component reaction of alkynes, 2-amino-1,1,3-tricyanopropylene, trichloroacetonitrile, and various amines or alcohols. The use of available catalysts and materials, CH₂Cl₂ solvent, carrying out the reaction under mild ultrasonic conditions for 50&#xa0;min, in the absence of ligands and oxidants, and the ease of purification methods for the synthesis of new and diverse substituted pyridines with amidine and imidate skeletons are among the advantages of this work.</p> Graphical Abstract <p></p>