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<p>Simultaneous voltammetric determination of acetaminophen and 4-aminophenol (hydrolytic degradation product of acetaminophen) is essential due to their high toxicity. In this work, the synthesis of Ni-based metal–organic framework nanosheets/graphene oxide (Ni–MOF NSs/GO) nanocomposite using solvothermal method and its performance as an electrode material for voltammetric determination of acetaminophen in the presence of 4-aminophenol are described. Due to the synergistic effects between Ni-MOF NSs and GO, the Ni-MOF NSs/GO nanocomposite-modified GCE demonstrated a considerable current response towards the redox process of acetaminophen in phosphate buffer solution at pH = 7.0. Under optimal conditions, the Ni-MOF NSs/GO/GCE sensing platform exhibited a good linear response in the concentration ranges from 0.1&#xa0;µM to 600&#xa0;µM for the quantification of acetaminophen using DPV method. The detection limit was determined to be 0.04&#xa0;µM. Also, the Ni-MOF NSs/GO/GCE could be used to determine simultaneously 4-aminophenol and acetaminophen with well separated oxidation peaks, using DPV measurements. The peak-to-peak separation of 4-aminophenol and acetaminophen was found to be 340&#xa0;mV. The analytical performance of the Ni-MOF NSs/GO-modified GCE was successfully showed by analyzing the contents of acetaminophen and 4-aminophenol in the acetaminophen tablet and water samples.</p> Graphical Abstract <p></p>

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Development of a novel electrochemical sensor for determination of acetaminophen in the presence of 4-aminophenol using Ni-MOF nanosheets/GO nanocomposite-modified glassy carbon electrode

  • 期刊论文

  • 发表日期：

    2025年6月17日

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  • Asma Sedrizadeh,
  • Niloufar Akbarzadeh-T,
  • Somayeh Tajik,
  • Hadi Beitollahi

摘要

Simultaneous voltammetric determination of acetaminophen and 4-aminophenol (hydrolytic degradation product of acetaminophen) is essential due to their high toxicity. In this work, the synthesis of Ni-based metal–organic framework nanosheets/graphene oxide (Ni–MOF NSs/GO) nanocomposite using solvothermal method and its performance as an electrode material for voltammetric determination of acetaminophen in the presence of 4-aminophenol are described. Due to the synergistic effects between Ni-MOF NSs and GO, the Ni-MOF NSs/GO nanocomposite-modified GCE demonstrated a considerable current response towards the redox process of acetaminophen in phosphate buffer solution at pH = 7.0. Under optimal conditions, the Ni-MOF NSs/GO/GCE sensing platform exhibited a good linear response in the concentration ranges from 0.1 µM to 600 µM for the quantification of acetaminophen using DPV method. The detection limit was determined to be 0.04 µM. Also, the Ni-MOF NSs/GO/GCE could be used to determine simultaneously 4-aminophenol and acetaminophen with well separated oxidation peaks, using DPV measurements. The peak-to-peak separation of 4-aminophenol and acetaminophen was found to be 340 mV. The analytical performance of the Ni-MOF NSs/GO-modified GCE was successfully showed by analyzing the contents of acetaminophen and 4-aminophenol in the acetaminophen tablet and water samples.

Graphical Abstract