Scholarlink

<p>Mussels demonstrate exceptional resistance to water adhesion and possess unique adhesive properties, serving as a biological model for designing advanced materials. Importantly, their adhesion process does not trigger immune responses, offering significant potential for biomimetic applications. Drawing inspiration from the principles of composite material design, polydipentaerythritol hexaacrylate and polyethylene glycol diacrylate were chosen as macromolecular backbones to replicate the adhesive properties of mussel adhesion proteins. A novel mussel-inspired adhesive, termed TAPE, was developed by grafting catechol moieties known for their adhesive functionality onto the polymer backbone via a Michael addition reaction. Experimental evaluations revealed that TAPE exhibits strong adhesion to diverse substrates, including ceramics, glass, and iron sheets. Notably, the adhesive achieved an adhesion strength of 45&#xa0;kPa on pig skin surfaces, surpassing the performance of commercially available tissue fiber adhesives by 4.5-fold. Cytotoxicity assessments further confirmed its low toxicity and excellent cytocompatibility. These findings highlight TAPE's potential as a versatile and biocompatible adhesive material, particularly suited for biomedical applications where robust adhesion and safety are critical. </p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development of a dopamine-based mussel-inspired adhesive with enhanced biocompatibility and adhesion properties

  • 期刊论文

  • 发表日期：

    2025年6月14日

查看全文
  • Yujun Zhu,
  • Said Alam,
  • Xiaoyu Shen,
  • Shaojun Zheng,
  • Chunhui Jiang,
  • Shu-Yang Chen,
  • Hongfei Lu

摘要

Mussels demonstrate exceptional resistance to water adhesion and possess unique adhesive properties, serving as a biological model for designing advanced materials. Importantly, their adhesion process does not trigger immune responses, offering significant potential for biomimetic applications. Drawing inspiration from the principles of composite material design, polydipentaerythritol hexaacrylate and polyethylene glycol diacrylate were chosen as macromolecular backbones to replicate the adhesive properties of mussel adhesion proteins. A novel mussel-inspired adhesive, termed TAPE, was developed by grafting catechol moieties known for their adhesive functionality onto the polymer backbone via a Michael addition reaction. Experimental evaluations revealed that TAPE exhibits strong adhesion to diverse substrates, including ceramics, glass, and iron sheets. Notably, the adhesive achieved an adhesion strength of 45 kPa on pig skin surfaces, surpassing the performance of commercially available tissue fiber adhesives by 4.5-fold. Cytotoxicity assessments further confirmed its low toxicity and excellent cytocompatibility. These findings highlight TAPE's potential as a versatile and biocompatible adhesive material, particularly suited for biomedical applications where robust adhesion and safety are critical.

Graphical abstract