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<p>Through a comprehensive analysis of the complete genomes of 74 global CaAstV strains, this study systematically untangles their evolutionary relationships and driving mechanisms. The research establishes a population structure comprising three major groups (GI, GII, GIII), with the GIII group exhibiting the highest genetic diversity due to high-frequency recombination events and further subdividing into three subgroups (GIII-1, -2, -3). Recombination is confirmed as a key evolutionary driver, with 88.9% (16/18) of the events concentrated within the GIII group, and hotspots identified in the ORF1ab and ORF2 regions. Profound group-specific amino acid variations are identified within the capsid protein (ORF2), with significant homology differences observed among the groups. Furthermore, phylogenetic analysis reveals a Japanese raccoon origin GII strain exhibiting high homology with the GII group, providing critical evidence for cross-species transmission. This study constructs a clear genotyping framework for CaAstV and elucidates the complete evolutionary pathway from recombination-driven diversity to protein adaptive variation, thereby laying a crucial foundation for its epidemiological research.</p>

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Evolutionary and phylogenetic insights from global canine astrovirus genomes

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Yihan Qiu,
  • Lijuan Lai,
  • Min Wang,
  • Haowei Yuan,
  • Jinghan Wu,
  • Ping Wang,
  • Mingxiang Li

摘要

Through a comprehensive analysis of the complete genomes of 74 global CaAstV strains, this study systematically untangles their evolutionary relationships and driving mechanisms. The research establishes a population structure comprising three major groups (GI, GII, GIII), with the GIII group exhibiting the highest genetic diversity due to high-frequency recombination events and further subdividing into three subgroups (GIII-1, -2, -3). Recombination is confirmed as a key evolutionary driver, with 88.9% (16/18) of the events concentrated within the GIII group, and hotspots identified in the ORF1ab and ORF2 regions. Profound group-specific amino acid variations are identified within the capsid protein (ORF2), with significant homology differences observed among the groups. Furthermore, phylogenetic analysis reveals a Japanese raccoon origin GII strain exhibiting high homology with the GII group, providing critical evidence for cross-species transmission. This study constructs a clear genotyping framework for CaAstV and elucidates the complete evolutionary pathway from recombination-driven diversity to protein adaptive variation, thereby laying a crucial foundation for its epidemiological research.