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<p>Leishmania RNA virus 2 (LRV2) has emerged as a potential molecular co-determinant of clinical outcomes in <i>Leishmania major</i> infections, particularly within the Old-World cutaneous leishmaniasis (CL) belt. Recent molecular investigations from Iran and adjacent endemic regions (2024-2025) have revealed extensive LRV2 diversity and phylogeographic structure. However, the lack of standardized assays, incomplete clinical metadata, and inconsistent reporting frameworks have hindered translation of detection findings into actionable public-health insights. This commentary synthesizes these findings and proposes a six-point, standards-based micro-protocol for harmonizing molecular detection, metadata collection, and clinical outcome recording, aimed at enhancing decision-useful surveillance and global comparability</p>

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Accumulating evidence, persistent uncertainty: Leishmania RNA virus 2 in Old-World cutaneous leishmaniasis – from detection to decision-useful surveillance

  • 期刊论文

  • 发表日期：

    2026年1月7日

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  • M. Vijayasimha

摘要

Leishmania RNA virus 2 (LRV2) has emerged as a potential molecular co-determinant of clinical outcomes in Leishmania major infections, particularly within the Old-World cutaneous leishmaniasis (CL) belt. Recent molecular investigations from Iran and adjacent endemic regions (2024-2025) have revealed extensive LRV2 diversity and phylogeographic structure. However, the lack of standardized assays, incomplete clinical metadata, and inconsistent reporting frameworks have hindered translation of detection findings into actionable public-health insights. This commentary synthesizes these findings and proposes a six-point, standards-based micro-protocol for harmonizing molecular detection, metadata collection, and clinical outcome recording, aimed at enhancing decision-useful surveillance and global comparability