Scholarlink

<p>Newcastle disease virus (NDV) and H9N2 avian influenza virus (AIV) have a severe impact on the poultry industry. This Iranian study evaluated Payavax G79®, an inactivated bivalent vaccine, in broiler chickens across five provinces. Vaccinated chicks showed robust antibody responses to both viruses via HI tests at 25 and 32 days post-vaccination. The vaccine provided complete protection against challenge with velogenic NDV genotype VII. However, H9N2 infection occurred on three farms, with 2% mortality. Molecular analysis of NDV isolates revealed amino acid substitutions in the hemagglutinin-neuraminidase protein that potentially enhance antigenicity. This study shows that Payavax G79® is highly immunogenic and provides significant protection against both NDV and H9N2 AIV under field conditions in Iran.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Immunogenetic insights into matching bivalent inactivated Payavax G79® for sustainable poultry vaccination against NDV-GVII and H9N2

  • 期刊论文

  • 发表日期：

    2025年12月5日

查看全文
  • Parisa Jamour,
  • Seyed Sajjad Babaeimarzangou,
  • Nima Daneshvar Hosseini,
  • Mostafa Gholizadeh Gigloo,
  • Rasa Sheini Mehrabzadeh,
  • Towhid Mohammadi,
  • Zohre Khademi,
  • Maryam Shafaati

摘要

Newcastle disease virus (NDV) and H9N2 avian influenza virus (AIV) have a severe impact on the poultry industry. This Iranian study evaluated Payavax G79®, an inactivated bivalent vaccine, in broiler chickens across five provinces. Vaccinated chicks showed robust antibody responses to both viruses via HI tests at 25 and 32 days post-vaccination. The vaccine provided complete protection against challenge with velogenic NDV genotype VII. However, H9N2 infection occurred on three farms, with 2% mortality. Molecular analysis of NDV isolates revealed amino acid substitutions in the hemagglutinin-neuraminidase protein that potentially enhance antigenicity. This study shows that Payavax G79® is highly immunogenic and provides significant protection against both NDV and H9N2 AIV under field conditions in Iran.