<p>This study examines the spatiotemporal changes in climate comfort across Iran, focusing on different land cover and elevation classes, along with future projections. The minimum Universal Thermal Climate Index (UTCI_min) gridded data from the ECMWF (European Centre for Medium-Range Weather Forecasts) database was employed for the base period (1985–2014), along with an ensemble of 8 GCMs for the near future (2030–2059) and far future (2060–2099) based on two Shared Socio-economic Pathways (SSP5-8.5 and SSP2-4.5). The results indicate that cold stress is the dominant phenomenon, affecting 99% of Iran’s area in January. The maximum extent of heat stress occurs in August, covering approximately 18% of the country. Under both scenarios, UTCI_min values are projected to rise in the future, leading to a contraction of cold stress areas and an increase in hot thermal stress, particularly in the far future under the SSP5-8.5 scenario. Trend analysis reveals a positive increase in UTCI_min values across parts of the study area, with more pronounced and widespread impacts in the far future. The effects of global warming on the UTCI_min index vary across different land cover and elevation classes. The results of this study will provide valuable insights for future research on climate comfort in Iran, serving as a basis for developing localized strategies to mitigate thermal stress and improve the resilience of the population to extreme temperature conditions.</p>