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Background <p>Parkinson’s disease-subjective cognitive decline (PD-SCD) is defined by subjective cognitive complaints (SCC) in the absence of objective cognitive impairment and has been associated with an increased risk of future cognitive decline. However, its impact on health-related quality of life (HRQoL) remains unclear. This is particularly relevant in early PD, when patients often maintain high levels of social-occupational functioning and subtle cognitive concerns may interfere with daily life. This study aimed to explore the association between SCC and HRQoL in cognitively unimpaired PD patients (PD-SCD).</p> Methods <p>Cross-sectional data from the COPPADIS cohort were analyzed. Patients with normal cognition according to PD-MCI level I criteria (Parkinson’s Disease-Cognitive Rating Scale &gt; 81) were included. HRQoL was assessed using the 39-item Parkinson’s Disease Questionnaire (PDQ-39). SCC were defined as a Non-Motor Symptoms Scale (NMSS) domain 5 ≥ 1.</p> Results <p>A total of 497 patients with median age 62 years, disease duration 4 years, and 61% of PD-SCD were included. HRQoL was significantly worse in PD-SCD patients across all PDQ-39 domains. In adjusted linear regression models, PD-SCD was independently associated with higher PDQ-39 total score as well as with worse scores in activities of daily living, social support, cognition, and communication domains.</p> Conclusions <p>PD-SCD is independently associated with poorer HRQoL across multiple domains. These findings highlight the clinical relevance of SCC within a patient-centered approach to PD management.</p>

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Parkinson’s disease-subjective cognitive decline and health-related quality of life

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Jon Rodriguez-Antiguedad,
  • Arnau Puig-Davi,
  • Carla Franch-Marti,
  • Lidia Bojtos,
  • Saül Martínez-Horta,
  • Javier Pagonabarraga,
  • María G. Alonso Losada,
  • Rubén Alonso Redondo,
  • María Álvarez Sauco,
  • María Asunción Ávila-Rivera,
  • Carmen Borrué,
  • Iria Cabo,
  • Nuria Caballol,
  • Esther Cubo,
  • Julio Dotor García-Soto,
  • Sonia Escalante,
  • Juan García Caldentey,
  • Rocío García-Ramos,
  • Itziar Gastón,
  • Guillermo González-Ortega,
  • Jorge Hernández-Vara,
  • Jon Infante,
  • Mónica Kurtis,
  • Bárbara Vives,
  • Nuria López Ariztegui,
  • Lydia López Manzanares,
  • Juan Carlos Martínez Castrillo,
  • Manuel Menéndez-González,
  • Carlos Ordás,
  • Gracia Pons Pons,
  • Alfredo Puy Núñez,
  • Javier Ruíz Martínez,
  • Pilar Sánchez-Alonso,
  • Manuel Seijo,
  • Berta Solano Vila,
  • Caridad Valero Merino,
  • Lydia Vela,
  • Pablo Mir,
  • Diego Santos-García,
  • A. D. Adarmes-Gómez,
  • A. Aldaz,
  • M. Almarcha Menargues,
  • M. Almeria Vivó,
  • M. G. Alonso Losada,
  • A. Alonso Cánovas,
  • R. Alonso Redondo,
  • M. Álvarez Sauco,
  • A. Ascunce Vidondo,
  • M. A. Ávila,
  • C. Borrue,
  • C. Cabello González,
  • I. Cabo López,
  • N. Caballol,
  • E. Carabajal Pendón,
  • F. Carrillo,
  • E. Casas,
  • A. M. Castellano Guerrero,
  • J. Castejón Carbó,
  • P. Clavero,
  • A. Cots Foraster,
  • E. Cubo,
  • T. de Deus Fonticoba,
  • P. Díaz Galván,
  • J. Dotor García-Soto,
  • S. Escalante,
  • E. Estelrich Peyret,
  • A. Fernández,
  • P. Franco Rosado,
  • P. Gámez,
  • M. Gallego,
  • J. García Caldentey,
  • R. García-Ramos,
  • I. Gastón,
  • P. Gómez Garre,
  • J. González Aloy,
  • I. González Aramburu,
  • B. González García,
  • M. J. González Palmás,
  • A. Golpe Díaz,
  • M. Grau Solá,
  • G. Guardia Valls,
  • J. Hernández Vara,
  • J. Infante,
  • S. Jesús,
  • J. Kulisevsky,
  • M. Kurtis,
  • C. Labandeira,
  • F. Lacruz,
  • I. Legarda Ramírez,
  • N. López Ariztegui,
  • D. López Domínguez,
  • L. López Manzanares,
  • E. López Valdés,
  • S. Lucas del Pozo,
  • A. C. Luque Ambrosiani,
  • Y. Macías,
  • D. Macías García,
  • M. A. Mandrá,
  • M. Mata,
  • J. C. Martínez Castrillo,
  • M. Menéndez González,
  • P. Mir,
  • J. Miranda Santiago,
  • M. I. Morales Casado,
  • L. Muñoz Delgado,
  • I. Muro García,
  • S. Novo Ponte,
  • E. Ojeda Lepe,
  • C. Ordás,
  • J. Pagonabarraga,
  • I. Pareés,
  • B. Pascual-Sedano,
  • A. Peral Quirós,
  • C. Pérez Calvo,
  • R. Pérez Noguera,
  • A. Planas-Ballvé,
  • G. Pons Pons,
  • M. A. Prats,
  • A. Puig Daví,
  • A. Puy Núñez,
  • N. Redondo Rafales,
  • C. Ribacoba,
  • M. Rivera Sánchez,
  • A. B. Rodríguez Pérez,
  • F. Roldán,
  • M. Roson,
  • J. Ruíz Martínez,
  • M. San Eufrasio Martínez,
  • P. Sánchez Alonso,
  • G. Sánchez Díez,
  • M. E. Sánchez Martín,
  • M. V. Sánchez Pelaez,
  • P. Santacruz,
  • D. Santos García,
  • M. Seijo,
  • M. Sierra Peña,
  • B. Solano Vila,
  • C. Solares,
  • A. Solleiro Vidal,
  • N. Suárez Fuentes,
  • G. Tabar Comellas,
  • A. Torres Moral,
  • C. Valero,
  • M. F. Valero García,
  • L. Vela,
  • B. Vives Pastor,
  • Jaime Kulisevsky

摘要

Background

Parkinson’s disease-subjective cognitive decline (PD-SCD) is defined by subjective cognitive complaints (SCC) in the absence of objective cognitive impairment and has been associated with an increased risk of future cognitive decline. However, its impact on health-related quality of life (HRQoL) remains unclear. This is particularly relevant in early PD, when patients often maintain high levels of social-occupational functioning and subtle cognitive concerns may interfere with daily life. This study aimed to explore the association between SCC and HRQoL in cognitively unimpaired PD patients (PD-SCD).

Methods

Cross-sectional data from the COPPADIS cohort were analyzed. Patients with normal cognition according to PD-MCI level I criteria (Parkinson’s Disease-Cognitive Rating Scale > 81) were included. HRQoL was assessed using the 39-item Parkinson’s Disease Questionnaire (PDQ-39). SCC were defined as a Non-Motor Symptoms Scale (NMSS) domain 5 ≥ 1.

Results

A total of 497 patients with median age 62 years, disease duration 4 years, and 61% of PD-SCD were included. HRQoL was significantly worse in PD-SCD patients across all PDQ-39 domains. In adjusted linear regression models, PD-SCD was independently associated with higher PDQ-39 total score as well as with worse scores in activities of daily living, social support, cognition, and communication domains.

Conclusions

PD-SCD is independently associated with poorer HRQoL across multiple domains. These findings highlight the clinical relevance of SCC within a patient-centered approach to PD management.