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<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms that significantly impact quality of life (QoL) of both patients and caregivers. This study investigates the effects of impulse control disorders (ICDs), depression, and apathy on the QoL of PD patients and the burden experienced by their caregivers. A sample of 130 PD patients and 113 corresponding caregivers was assessed. Patients were evaluated using the Questionnaire for Impulsive-Compulsive Disorders in PD, Hamilton Rating Scale for Depression, Apathy Evaluation Scale, Barratt Impulsiveness Scale − 11, and Parkinson’s Disease Questionnaire, while caregivers completed the Multidimensional Caregiver Strain Index. Repeated measures T-tests, correlation analyses, and multiple linear regressions were performed to explore associations between clinical, behavioral, and QoL variables. Results revealed that depression and apathy were significantly associated with poorer QoL in patients. ICDs showed a significant correlation with illness duration and poorer patient QoL. Trait impulsivity was strongly associated with both patient and caregiver outcomes, emerging as a key predictor of both caregiver burden (<i>p</i> = 0.026) and patient QoL (<i>p</i> = 0.001). Notably, only impulsivity trait significantly affected both groups. These findings emphasize the importance of assessing impulsive personality traits early in the course of PD in order to anticipate and mitigate both patient disability and caregiver strain. The study underscores the interconnectedness of neuropsychiatric symptoms and caregiver burden, suggesting that interventions targeting impulsivity may benefit both patients and their support networks.</p>

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Caregiver burden of parkinsonian patients with impulse control disorders, depression and apathy

  • 期刊论文

  • 发表日期：

    2026年4月21日

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  • Francesca Rugolo,
  • Pasquale Nigro,
  • Michele Romoli,
  • Silvia Sperandei,
  • Francesco Palombo,
  • Federico Paolini Paoletti,
  • Lucilla Parnetti,
  • Valerio Santangelo,
  • Nicola Tambasco

摘要

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms that significantly impact quality of life (QoL) of both patients and caregivers. This study investigates the effects of impulse control disorders (ICDs), depression, and apathy on the QoL of PD patients and the burden experienced by their caregivers. A sample of 130 PD patients and 113 corresponding caregivers was assessed. Patients were evaluated using the Questionnaire for Impulsive-Compulsive Disorders in PD, Hamilton Rating Scale for Depression, Apathy Evaluation Scale, Barratt Impulsiveness Scale − 11, and Parkinson’s Disease Questionnaire, while caregivers completed the Multidimensional Caregiver Strain Index. Repeated measures T-tests, correlation analyses, and multiple linear regressions were performed to explore associations between clinical, behavioral, and QoL variables. Results revealed that depression and apathy were significantly associated with poorer QoL in patients. ICDs showed a significant correlation with illness duration and poorer patient QoL. Trait impulsivity was strongly associated with both patient and caregiver outcomes, emerging as a key predictor of both caregiver burden (p = 0.026) and patient QoL (p = 0.001). Notably, only impulsivity trait significantly affected both groups. These findings emphasize the importance of assessing impulsive personality traits early in the course of PD in order to anticipate and mitigate both patient disability and caregiver strain. The study underscores the interconnectedness of neuropsychiatric symptoms and caregiver burden, suggesting that interventions targeting impulsivity may benefit both patients and their support networks.