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<p>The association of household pesticide exposure with Parkinson’s disease has been less explored than occupational exposure. Using data from the Parkinson's Progression Markers Initiative and the Fox Insight study, we analyzed the association between household pesticide exposure and the risk of developing Parkinson’s disease, as well as the age at onset. We analyzed data from 2,847 individuals with Parkinson’s disease and 385 healthy controls. The odds of developing Parkinson’s disease were two times higher in people with high use of household herbicides (adjusted OR = 1.95, 95% CI 1.14–3.32, p = 0.014) and any pesticides (adjusted OR = 1.83, 95% CI 1.16–2.89, p = 0.008). Also, a higher use of household herbicides (adjusted OR = 1.13, 95% CI 1.00–1.27, p = 0.038) and any pesticides (adjusted OR = 1.11, 95% CI 1.00–1.23, p = 0.033) before the age of 35&#xa0;years old was associated with higher odds of developing early-onset PD. High household exposure to herbicides and other pesticides may increase the risk of developing Parkinson’s disease and lead to an earlier onset of the disease.</p>

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Household herbicide use is associated with the risk of Parkinson’s disease and a younger age at onset in PPMI and Fox Insight cohorts

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Bruno Lopes Santos-Lobato,
  • Artur F. S. Schuh,
  • Ignacio F. Mata

摘要

The association of household pesticide exposure with Parkinson’s disease has been less explored than occupational exposure. Using data from the Parkinson's Progression Markers Initiative and the Fox Insight study, we analyzed the association between household pesticide exposure and the risk of developing Parkinson’s disease, as well as the age at onset. We analyzed data from 2,847 individuals with Parkinson’s disease and 385 healthy controls. The odds of developing Parkinson’s disease were two times higher in people with high use of household herbicides (adjusted OR = 1.95, 95% CI 1.14–3.32, p = 0.014) and any pesticides (adjusted OR = 1.83, 95% CI 1.16–2.89, p = 0.008). Also, a higher use of household herbicides (adjusted OR = 1.13, 95% CI 1.00–1.27, p = 0.038) and any pesticides (adjusted OR = 1.11, 95% CI 1.00–1.23, p = 0.033) before the age of 35 years old was associated with higher odds of developing early-onset PD. High household exposure to herbicides and other pesticides may increase the risk of developing Parkinson’s disease and lead to an earlier onset of the disease.